Case Report

Metaplastic Breast Carcinoma with Osseous Differentiation: A Case Report

Authors: Jeffrey M. Pollock, MD, Allan Green, MD, Cynthia Donnell, MD, Donna Lynn Dyess, MD, J Allan Tucker, MD

Abstract

Metaplastic breast carcinoma is a rare entity with the distinguishing feature of having epithelial and mesenchymal tissue types incorporated within one tumor. This is a case report of a patient found to have a rare metaplastic breast carcinoma with prominent osseous differentiation. Radiologic and pathologic correlation is provided.


Key Points


* Metaplastic breast carcinoma is a rare form of breast cancer with a variety of presentations dependent on the tissue subtypes incorporated within the lesion.

This content is limited to qualifying members.

Existing members, please login first

If you have an existing account please login now to access this article or view purchase options.

Purchase only this article ($25)

Create a free account, then purchase this article to download or access it online for 24 hours.

Purchase an SMJ online subscription ($75)

Create a free account, then purchase a subscription to get complete access to all articles for a full year.

Purchase a membership plan (fees vary)

Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

References

1. Kaufman MW, Marti JR, Gallager S, et al. Carcinoma of the breast with pseudosarcomatous metaplasia.  | Cancer 1984;53:1908–1917.
 
2. Smith DM, Rongaus VA, Wehmann TW, et al. Metaplastic breast carcinoma. J Am Osteopath Association 1996;96:419–421.
 
3. Johnson TL, Kini SR. Metaplastic breast carcinoma. a cytohistologic and clinical study of 10 cases.Diagnostic Cytopathology 1996;14:226–232.
 
4. Greenberg D, McIntyre H, Bierre T. Metaplastic Breast Cancer. Australasian Radiology 2004;48:243–247.
 
5. Rayson D, Adjei AA, Suman VJ, et al. Metaplastic breast cancer: prognosis and response to systemic therapy. Annals of Oncology 1999;10:413–419.
 
6. Park JM, Han BK, Moon WK, et al. Metaplastic carcinoma of the breast: mammographic and sonographic findings. Journal of Clinical Ultrasound 2000;28:179–186.
 
7. Elston CW, Ellis IO. Vol. 13. The Breast. In: Systemic Pathology, 3rd ed. Churchill Livingstone, Edinburgh, 1998, pp 323–328.
 
8. Oberman HA. Metaplastic carcinoma of the breast. A clinicopathologic study of 29 patients. Am J Surg Pathol 1987;11:918–929.
 
9. Chhieng C, Cranor M, Lesser ME, et al. Metaplastic carcinoma of the breast with osteocartilaginous heterologous elements. Am J Surg Pathol 1998;22:188–194.
 
10. Park JM, Han BK, Moon WK, et al. Metaplastic carcinoma of the breast: mammographic and sonographic findings. J Clin Ultrasound 2000;28:179–186.
 
11. Brenner RJ, Turner RR, Schiller V, et al. Metaplastic carcinoma of the breast: report of three cases.Cancer 1998;82:1082–1087.
 
12. Evans HA, Shaughnessy EA, Nikiforov YE. Infiltrating ductal carcinoma of the breast with osseous metaplasia: imaging findings with pathologic correlation. AJR 1999;172:1420–1422.
 
13. Patterson SK, Tworek JA, Roubidoux MA, et al. Metaplastic carcinoma of the breast: mammographic appearance with pathologic correlation. AJR 1997;169:709–712.
 
14. Velasco M, Santamaria G, Ganau S, et al. MRI of metaplastic carcinoma of the breast. AJR2005;184:1274–1278.
 
15. Günhan-Bilgen I, Memis A, Üstün EE, et al. Metaplastic carcinoma of the breast: clinical, mammographic, and sonographic findings with histopathologic correlation. AJR 2002;178:1421–1425.