Case Report

Multifocal Primary Breast Lymphoma

Authors: Randal Baker, MD, Geoffrey Slayden, MD, William Jennings, MD

Abstract

Primary breast lymphoma (PBL) is a rare condition, accounting for only 0.04 to 0.5% of breast malignancies and less than 2% of extranodal lymphomas. Clinical presentation and imaging may suggest a benign condition. Reports of treatment vary widely. Surgical therapy has been reported to include only biopsy or extend to partial mastectomy, total mastectomy, or even radical mastectomy. Chemotherapy with various agents is often used. Radiotherapy has been used in the adjuvant setting or as primary local therapy. Immunotherapy and radioimmunotherapy have shown some promise in other lymphomas and may be useful here as well. There is no standard or consensus of treatment for PBL. This report describes a case of multifocal PBL in a 45-year-old female and discusses the physical findings, diagnosis, and treatment options for this condition.


Key Points


* An adequate pathologic specimen is needed that demonstrates close association of the lymphomatous infiltrate and breast tissue.


* There should be no evidence of concurrent widespread disease or preceding extramammary lymphoma.


* The breast must be the clinical site of presentation, but ipsilateral lymph node involvement is considered acceptable if both lesions develop simultaneously.

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