Editorial

Plasma Homocysteine Level and Myocardial Infarction: How High is High Enough to Need Intervention?

Authors: Kanjaksha Ghosh, MD, MRCPI, MRCP (UK), FRC, Path (Lond), FACP, FICP, FAMS, FNASC

Abstract

Several studies have shown the association of acute myocardial infarction with high plasma homocysteine levels.1–4 These studies involved different populations and have involved different study designs. However, retrospective studies tend to show a higher degree of positive association with hyperhomocystinemia than prospective studies. In some studies, no association was found.5,6 In this issue of theJournal, Marouf et al7 showed a mild increase in plasma homocysteine levels in a group of patients with acute myocardial infarction in a case control study.

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