Abstract
Abstract:Extraskeletal dedifferentiated chondrosarcomas (DC) are uncommon tumors that predominantly occur in the head and neck. Herein, we describe a case of pulmonary DC detected in a patient with systemic sclerosis and presenting with a symptomatic large pleural effusion and a pulmonary lobar consolidation on chest imaging. To the best of our knowledge, this is the first report of pulmonary chondrosarcoma involving the pleura and occurring in association with systemic sclerosis. Moreover, this is the second report of a dedifferentiated variant among all reported cases of primary lung chondrosarcoma.
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References
References1. Dorfman HD, Czerniak B. Bone cancers. Cancer 1995;75(1 suppl):203–210.DorfmanHD]]CzerniakBBone cancers.Cancer199575203-2102. Steurer S, Huber M, Lintner F. Dedifferentiated chondrosarcoma of the lung: case report and review of the literature. Clin Lung Cancer 2007;8:439–442.SteurerS]]HuberM]]LintnerFDedifferentiated chondrosarcoma of the lung: case report and review of the literature.Clin Lung Cancer20078439-4423. Johnson S, Têtu B, Ayala AG, et al. Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). I. A clinicopathologic study of 26 cases. Cancer 1986;58:278–286.JohnsonS]]TêtuB]]AyalaAG&etal;Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). I. A clinicopathologic study of 26 cases.Cancer198658278-2864. Frassica FJ, Unni KK, Beabout JW, et al. Dedifferentiated chondrosarcoma. A report of the clinicopathological features and treatment of seventy-eight cases. J Bone Joint Surg Am 1986;68:1197–1205.FrassicaFJ]]UnniKK]]BeaboutJW&etal;Dedifferentiated chondrosarcoma. A report of the clinicopathological features and treatment of seventy-eight cases.J Bone Joint Surg Am1986681197-12055. Huang HY, Hsieh MJ, Chen WJ, et al. Primary mesenchymal chondrosarcoma of the lung. Ann Thorac Surg 2002;73:1960–1962.HuangHY]]HsiehMJ]]ChenWJ&etal;Primary mesenchymal chondrosarcoma of the lung.Ann Thorac Surg2002731960-19626. Thompson AE, Pope JE. A study of the frequency of pericardial and pleural effusions in scleroderma. Br J Rheumatol 1998;37:1320–1323.ThompsonAE]]PopeJEA study of the frequency of pericardial and pleural effusions in scleroderma.Br J Rheumatol1998371320-13237. Huggins JT, Sahn SA. Drug-induced pleural disease. Clin Chest Med 2004;25:141–153.HugginsJT]]SahnSADrug-induced pleural disease.Clin Chest Med200425141-1538. Wooten M. Systemic sclerosis and malignancy: a review of the literature. South Med J 2008;101:59–62.WootenMSystemic sclerosis and malignancy: a review of the literature.South Med J200810159-629. Ciołkiewicz M, Domysławska I, Ciołkiewicz A, et al. Coexistence of systemic sclerosis, scleroderma-like syndromes and neoplastic diseases. Pol Arch Med Wewn 2008;118:119–126.CiołkiewiczM]]DomysławskaI]]CiołkiewiczA&etal;Coexistence of systemic sclerosis, scleroderma-like syndromes and neoplastic diseases.Pol Arch Med Wewn2008118119-12610. Roumm AD, Medsger TA Jr. Cancer and systemic sclerosis. An epidemiologic study. Arthritis Rheum 1985;28:1336–1340.RoummAD]]MedsgerTAJrCancer and systemic sclerosis. An epidemiologic study.Arthritis Rheum1985281336-134011. Higuchi M, Horiuchi T, Ishibashi N, et al. Anticentromere antibody as a risk factor for cancer in patients with systemic sclerosis. Clin Rheumatol 2000;19:123–126.HiguchiM]]HoriuchiT]]IshibashiN&etal;Anticentromere antibody as a risk factor for cancer in patients with systemic sclerosis.Clin Rheumatol200019123-12612. Sakkas LI, Moore DF, Akritidis NC. Cancer in families with systemic sclerosis. Am J Med Sci 1995;310:223–225.SakkasLI]]MooreDF]]AkritidisNCCancer in families with systemic sclerosis.Am J Med Sci1995310223-22513. Tremblay F, Fernandes M, Habbab F, et al. Malignancy after renal transplantation: incidence and role of type of immunosuppression. Ann Surg Oncol 2002;9:785–788.TremblayF]]FernandesM]]HabbabF&etal;Malignancy after renal transplantation: incidence and role of type of immunosuppression.Ann Surg Oncol20029785-78814. Kudo N, Ogose A, Hotta T, et al. Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation. Virchows Arch 2007;451:691–699.KudoN]]OgoseA]]HottaT&etal;Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation.Virchows Arch2007451691-699