Perspectives

CME Article: Psychiatric Aspects of Sickle Cell Disease

Authors: C. Patrick Carroll, MD

Abstract

There is little specific research on common psychiatric conditions in sickle cell disease (SCD). Conditions involving chronic pain are known to co-occur with depression and anxiety to a high degree, and greater chronicity and severity of pain tend to be linked more closely with both depressive symptoms and the diagnosis of major depressive disorder.1–7 Causal relations between chronic pain and psychiatric comorbidity are difficult to elucidate for a number of reasons, but the current state of evidence suggests a bidirectional relation.8

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