Primary Article
Relapsing Polychondritis
Abstract
Abstract:Two cases of relapsing polychondritis are presented to emphasize the variety of clinical features and the seriousness of problems encountered with involvement of the cartilaginous portion of the respiratory tree. Inflammation of cartilage characterizes the syndrome, while it also affects such structures as the inner ear, sclera, and anterior uveal tract, which are devoid of cartilage. The cause of the disease remains obscure. Evidence is reviewed to suggest that the cause is either an acquired metabolic derangement or, more likely, an immune disorder with the production of autoantibodies to a substance common to cartilage and other involved organs, possibly the acid mucopolysaccharides. During acute exacerbations, these mucopolysaccharides are recoverable in the urine. Early diagnosis and treatment with corticosteroids are important.This content is limited to qualifying members.
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