References

References 1. Campbell S, Whitehead M. Oestrogen therapy and the menopausal syndrome. Clin Obstet Gynecol 1977; 4: 33–47.CampbellS]]WhiteheadMOestrogen therapy and the menopausal syndromeClin Obstet Gynecol1977433 2. The Writing Group for the PEPI Trial. Effects of hormone therapy on bone mineral density: Results from the Post-Menopausal Estrogen/Progestin Intervention Trial. JAMA 1996; 276: 1389–1396.The Writing Group for the PEPI Trial.Effects of hormone therapy on bone mineral density: Results from the Post-Menopausal Estrogen/Progestin Intervention TrialJAMA19962761389 3. The Writing Group for the PEPI Trial. The effects of estrogen or estrogen/progesterone regimens on heart disease risk factors in postmenopausal women. JAMA 1995; 273: 199–208.The Writing Group for the PEPI Trial.The effects of estrogen or estrogen/progesterone regimens on heart disease risk factors in postmenopausal womenJAMA1995273199 4. Grodstein F, Stampfer MS, Colditz GA, Willett WL, Mansan JE, Joffee M, et al. Postmenopausal estrogen therapy and mortality. N Engl J Med 1997; 336: 1769–1775.GrodsteinF]]StampferMS]]ColditzGA]]WillettWL]]MansanJE]]JoffeeMPostmenopausal estrogen therapy and mortalityN Engl J Med19973361769 5. Schairer C, Lubin J, Troisi R, Sturgeon S, Brinton L, Hoover R, et al. Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk. JAMA 2000; 283: 485–491.SchairerC]]LubinJ]]TroisiR]]SturgeonS]]BrintonL]]HooverRMenopausal estrogen and estrogen-progestin replacement therapy and breast cancer riskJAMA2000283485 6. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998; 280: 605–613.HulleyS]]GradyD]]BushT]]FurbergC]]HerringtonD]]RiggsBRandomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal womenJAMA1998280605 7. Jordan VC. Designer estrogens. Sci Am 1998; 279: 60–67.JordanVCDesigner estrogensSci Am199827960 8. Greene GL, Gilna P, Waterfield M, Barber A, Hort Y, Shine J. Sequence and expression of human estrogen receptor complementary DNA. Science 1986; 231: 1150–1154.GreeneGL]]GilnaP]]WaterfieldM]]BarberA]]HortY]]ShineJSequence and expression of human estrogen receptor complementary DNAScience19862311150 9. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor in rat prostate and ovary. Proc Natl Acad Sci U S A 1996; 93: 5925–5930.KuiperGG]]EnmarkE]]Pelto-HuikkoM]]NilssonS]]GustafssonJACloning of a novel receptor in rat prostate and ovaryProc Natl Acad Sci U S A1996935925 10. Peterson CM. Estrogen and progesterone receptors: An overview for the year 2000. J Soc Gynecol Investig 2000; 7( 1 Suppl): S3–S7.PetersonCMEstrogen and progesterone receptors: An overview for the year 2000J Soc Gynecol Investig20007S3 11. Hurd C, Moudgil VK. Steroid hormone receptor families, in Conn PM, Goodman HM (eds): Handbook of Physiology: Section 7—The Endocrine System: Volume 1—Cellular Endocrinology. New York, Oxford University Press, 1998, pp 383–411. 12. Shibata H, Spencer TE, Ohate SA, Jenster G, Tsai SY, Omalley BW. Role of coactivators and corepressors in the mechanism of steroid/thyroid receptor action. Recent Prog Horm Res 1997; 52: 141–165.ShibataH]]SpencerTE]]OhateSA]]JensterG]]TsaiSY]]OmalleyBWRole of coactivators and corepressors in the mechanism of steroid/thyroid receptor actionRecent Prog Horm Res199752141 13. Giguere V, Tremblay A, Tremblay GB. Estrogen receptor B: Reevaluation of estrogen and anti-estrogen signaling. Steroids 1998; 63: 335–339.GiguereV]]TremblayA]]TremblayGBEstrogen receptor B: Reevaluation of estrogen and anti-estrogen signalingSteroids199863335 14. Adashi EY. Ovulation induction: clomiphene citrate, in Adashi EY, Rock JA, Rosenwaks Z (eds): Reproductive Endocrinology, Surgery, and Technology. Philadelphia, Lippincott-Raven, 1996, pp 1181–1206. 15. Stewart PJ, Stern PH. Effects of antiestrogens tamoxifen and clomiphene on bone resorption in vitro. Endocrinology 1986; 8: 125–131.StewartPJ]]SternPHEffects of antiestrogens tamoxifen and clomiphene on bone resorption in vitroEndocrinology19868125 16. Plouffe L. Selective estrogen receptor modulators in clinical practice. J Soc Gynecol Investig 2000; 7( 1 Suppl): S38–S46.PlouffeLSelective estrogen receptor modulators in clinical practiceJ Soc Gynecol Investig20007S38 17. Jones GS, Demoraes-Ruehsen N. Induction of ovulation with human gonadotropins with clomiphene. Fertil Steril 1965; 16: 461.JonesGS]]Demoraes-RuehsenNInduction of ovulation with human gonadotropins with clomipheneFertil Steril196516461 18. Zeneca Pharmaceuticals. Nolvadex (package insert). Wilmington, DE, Zeneca Pharmaceuticals, 1998. 19. Barr Laboratories. Tamoxifen citrate (package insert). Pomona, NY, Barr Laboratories. 20. Jordan VC. Molecular mechanisms of antiestrogen action in breast cancer. Breast Cancer Res Treat 1994; 31: 41–52.JordanVCMolecular mechanisms of antiestrogen action in breast cancerBreast Cancer Res Treat19943141 21. Murphy LC. Antiestrogen action and growth factor regulation. Breast Cancer Res Treat 1994; 31: 61–71.MurphyLCAntiestrogen action and growth factor regulationBreast Cancer Res Treat19943161 22. Haran FE, Maretzek AF, Goldberg I, Horowitz A, Degani H. Tamoxifen enhances cell death in implanted MLF7 breast cancer by inhibiting endothelium growth. Cancer Res 1994; 54: 5511–5514.HaranFE]]MaretzekAF]]GoldbergI]]HorowitzA]]DeganiHTamoxifen enhances cell death in implanted MLF7 breast cancer by inhibiting endothelium growthCancer Res1994545511 23. The Early Breast Cancer Trialists’ Collaborative Group. Tamoxifen for early breast cancer: An overview of the randomised trials. Lancet 1998; 351: 1451–1467.The Early Breast Cancer Trialists’ Collaborative Group.Tamoxifen for early breast cancer: An overview of the randomised trialsLancet19983511451 24. Saez RA, Osborne CK. Hormonal treatment of advanced breast cancer, in Kennedy BJ (ed): Current Clinical Oncology: Breast Cancer. New York, Alan R. Liss, 1989, vol 1, pp 163–172. 25. Ravdin PM, Green S, Dorr TM, McGuire WL, Fabian C, Pugh RP, et al. Prognostic significance of progesterone receptor levels in estrogen receptor positive patients with metastatic breast cancer treated with tamoxifen: Results of a prospective South West Oncology Group study. J Clin Oncol 1992; 10: 1284–1291.RavdinPM]]GreenS]]DorrTM]]McGuireWL]]FabianC]]PughRPPrognostic significance of progesterone receptor levels in estrogen receptor positive patients with metastatic breast cancer treated with tamoxifen: Results of a prospective South West Oncology Group studyJ Clin Oncol1992101284 26. Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, et al. Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 1998; 90: 1371–1388.FisherB]]CostantinoJP]]WickerhamDL]]RedmondCK]]KavanahM]]CroninWMTamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 StudyJ Natl Cancer Inst1998901371 27. Powles T, Eeles R, Ashley S, Easton D, Chang J, Dowsett M, et al. Interim analysis of incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomized chemoprevention trial. Lancet 1998; 352: 98–101.PowlesT]]EelesR]]AshleyS]]EastonD]]ChangJ]]DowsettMInterim analysis of incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomized chemoprevention trialLancet199835298 28. Veronesi U, Maisonneuve P, Costa A, Sacchini V, Maltoni C, Robertson C, et al. Prevention of breast cancer with tamoxifen: Preliminary findings from the Italian randomized trial among hyste rectomized women. Lancet 1998; 352: 93–97.VeronesiU]]MaisonneuveP]]CostaA]]SacchiniV]]MaltoniC]]RobertsonCPrevention of breast cancer with tamoxifen: Preliminary findings from the Italian randomized trial among hysterectomized womenLancet199835293 29. Mitlak BH, Cohen FJ. Selective estrogen receptor modulators: A look ahead. Drugs 1999; 57: 653–663.MitlakBH]]CohenFJSelective estrogen receptor modulators: A look aheadDrugs199957653 30. Goldstein SR. Effect of SERMs on breast tissue. J Endocrinol Invest 1999; 22: 636–640.GoldsteinSREffect of SERMs on breast tissueJ Endocrinol Invest199922636 31. Turken S, Siris E, Seldin D, Flaster E, Hyman G, Lindsay R. Effects of tamoxifen on spinal bone density in women with breast cancer. J Natl Cancer Inst 1989; 81: 1086–1088.TurkenS]]SirisE]]SeldinD]]FlasterE]]HymanG]]LindsayREffects of tamoxifen on spinal bone density in women with breast cancerJ Natl Cancer Inst1989811086 32. Love RR, Mazess RB, Barden HS, Epstein S, Newcomb PA, Jordan VC, et al. Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. N Engl J Med 1992; 326: 852–856.LoveRR]]MazessRB]]BardenHS]]EpsteinS]]NewcombPA]]JordanVCEffects of tamoxifen on bone mineral density in postmenopausal women with breast cancerN Engl J Med1992326852 33. Delmas PD, Balena R, Contavreux E, Hardouin C, Hardy P, Bremond A. Bisphosphonate risedronate prevents bone loss in women with artificial menopause due to chemotherapy of breast cancer: A double-blind placebo controlled study. J Clin Oncol 1997; 15: 955–962.DelmasPD]]BalenaR]]ContavreuxE]]HardouinC]]HardyP]]BremondABisphosphonate risedronate prevents bone loss in women with artificial menopause due to chemotherapy of breast cancer: A double-blind placebo controlled studyJ Clin Oncol199715955 34. Breuer B, Wallenstein S, Anderson R. The effect of tamoxifen on bone fracture in older nursing home residents. J Am Geriatr Soc 1998; 40: 968–972.BreuerB]]WallensteinS]]AndersonRThe effect of tamoxifen on bone fracture in older nursing home residentsJ Am Geriatr Soc199840968 35. Powles TJ, Hickish T, Kanis JA, Tidy A, Ashley S. Effect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal women. J Clin Oncol 1996; 14: 78–84.PowlesTJ]]HickishT]]KanisJA]]TidyA]]AshleySEffect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal womenJ Clin Oncol19961478 36. Love RR, Wiebe DA, Feyzi JM, Newcomb PA, Chappell RJ. Effects of tamoxifen on cardiovascular risk factors in postmenopausal women after 5 years of treatment. J Natl Cancer Inst 1994; 86: 1534–1539.LoveRR]]WiebeDA]]FeyziJM]]NewcombPA]]ChappellRJEffects of tamoxifen on cardiovascular risk factors in postmenopausal women after 5 years of treatmentJ Natl Cancer Inst1994861534 37. Grey AB, Stapleton JP, Evans MC, Reid JR. The effect of the anti-estrogen tamoxifen on cardiovascular risk factors in normal postmenopausal women. J Clin Endocrinol Metab 1995; 80: 3191–3195.GreyAB]]StapletonJP]]EvansMC]]ReidJRThe effect of the anti-estrogen tamoxifen on cardiovascular risk factors in normal postmenopausal womenJ Clin Endocrinol Metab1995803191 38. Guetta V, Lush RM, Figg WD, Waclawiw MA, Cannon RO III. Effects of the antiestrogen tamoxifen on low-density lipoprotein concentrations and oxidation in postmenopausal women. Am J Cardiol 1995; 76: 1672–1673.GuettaV]]LushRM]]FiggWD]]WaclawiwMA]]CannonROEffects of the antiestrogen tamoxifen on low-density lipoprotein concentrations and oxidation in postmenopausal womenAm J Cardiol1995761672 39. Chang J, Powles TJ, Ashley SE, Gregory RK, Tidy VA, Treleaven JG, et al. The effect of tamoxifen and hormone replacement therapy on serum cholesterol, bone mineral density and coagulation factors in healthy postmenopausal women participating in a randomised, controlled tamoxifen prevention study. Ann Oncol 1996; 7: 671–675.ChangJ]]PowlesTJ]]AshleySE]]GregoryRK]]TidyVA]]TreleavenJGThe effect of tamoxifen and hormone replacement therapy on serum cholesterol, bone mineral density and coagulation factors in healthy postmenopausal women participating in a randomised, controlled tamoxifen prevention studyAnn Oncol19967671 40. Shewmon DA, Stock JL, Rosen CJ, Heiniluoma KM, Hogue MM, Morrison A, et al. Tamoxifen and estrogen lower circulating lipoprotein (a) concentrations in healthy postmenopausal women. Arterioscler Thromb 1994; 14: 1586.ShewmonDA]]StockJL]]RosenCJ]]HeiniluomaKM]]HogueMM]]MorrisonATamoxifen and estrogen lower circulating lipoprotein (a) concentrations in healthy postmenopausal womenArterioscler Thromb1994141586 41. Cattaneo M, Baglietto L, Zighetti ML, Bettega D, Robertson C, Costa A, et al. Tamoxifen reduces plasma homocysteine levels in healthy women. Br J Cancer 1998; 77: 2264–2266.CattaneoM]]BagliettoL]]ZighettiML]]BettegaD]]RobertsonC]]CostaATamoxifen reduces plasma homocysteine levels in healthy womenBr J Cancer1998772264 42. McDonald CC, Alexander FE, Whyte BW, Forrest AP, Stewart HJ. Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomized trial: The Scottish Cancer Trials Breast Group. BMJ 1995; 311: 977–980.McDonaldCC]]AlexanderFE]]WhyteBW]]ForrestAP]]StewartHJCardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomized trial: The Scottish Cancer Trials Breast GroupBMJ1995311977 43. Rutqvist LE, Mattsson A. Cardiac and thromboembolic morbidity among post-menopausal women with early stage breast cancer in a randomized trial of adjuvant tamoxifen: The Stockholm Breast Cancer Study Group. J Natl Cancer Inst 1993; 85: 1398–1406.RutqvistLE]]MattssonACardiac and thromboembolic morbidity among post-menopausal women with early stage breast cancer in a randomized trial of adjuvant tamoxifen: The Stockholm Breast Cancer Study GroupJ Natl Cancer Inst1993851398 44. Schagen SB, van Dam F, Muller MJ, Boogerd W, Lindeboom J, Bruning P. Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma. Cancer 1999; 85: 640–650.SchagenSB]]van DamF]]MullerMJ]]BoogerdW]]LindeboomJ]]BruningPCognitive deficits after postoperative adjuvant chemotherapy for breast carcinomaCancer199985640 45. Cyr M, Landry M, Dipaolo T. Modulation by estrogen receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain. Neuropsychopharmacology 2000; 23: 69–77.CyrM]]LandryM]]DipaoloTModulation by estrogen receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brainNeuropsychopharmacology20002369 46. Lahti E, Blanco G, Kauppila A, Apaja-Sarkkinen M, Taskinen PJ, Laatikainen T. Endometrial changes in postmenopausal breast cancer patients receiving tamoxifen. Obstet Gynecol 1993; 81: 660–664.LahtiE]]BlancoG]]KauppilaA]]Apaja-SarkkinenM]]TaskinenPJ]]LaatikainenTEndometrial changes in postmenopausal breast cancer patients receiving tamoxifenObstet Gynecol199381660 47. Kedar RP, Bourne TH, Powles TJ, Collins WP, Ashley SE, Cosgrove DO, et al. Effects of tamoxifen on the uterus and ovaries of postmenopausal women in a randomised breast cancer prevention trial. Lancet 1994; 343: 1318–1321.KedarRP]]BourneTH]]PowlesTJ]]CollinsWP]]AshleySE]]CosgroveDOEffects of tamoxifen on the uterus and ovaries of postmenopausal women in a randomised breast cancer prevention trialLancet19943431318 48. Barakat RR. Tamoxifen and the endometrium. Cancer Treat Res 1998; 94: 195–207.BarakatRRTamoxifen and the endometriumCancer Treat Res199894195 49. Fisher B, Costantino JP, Redmond CK, Fisher ER, Wickerham DL, Cronin WM. Endometrial cancer in tamoxifen-treated breast cancer patients: Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. J Natl Cancer Inst 1994; 86: 527–537.FisherB]]CostantinoJP]]RedmondCK]]FisherER]]WickerhamDL]]CroninWMEndometrial cancer in tamoxifen-treated breast cancer patients: Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14J Natl Cancer Inst199486527 50. Stearns V, Gelman EP. Does tamoxifen cause cancer in humans? J Clin Oncol 1998; 16: 779.StearnsV]]GelmanEPDoes tamoxifen cause cancer in humans?J Clin Oncol199816779 51. Robinson E, Kimmick GG, Muss HB. Tamoxifen in postmenopausal women: A safety perspective. Drugs Aging 1996; 8: 329–337.RobinsonE]]KimmickGG]]MussHBTamoxifen in postmenopausal women: A safety perspectiveDrugs Aging19968329 52. Hayes DF, Van Zyl JA, Hacking A, Goedhals L, Bezwoda WR, Mailliard JA, et al. Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients with metastatic breast cancer. J Clin Oncol 1995; 13: 2556.HayesDF]]Van ZylJA]]HackingA]]GoedhalsL]]BezwodaWR]]MailliardJARandomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients with metastatic breast cancerJ Clin Oncol1995132556 53. Gershanovich M, Hayes DJ, Ellman J, Vuorinen J. High-dose toremifene versus tamoxifen in postmenopausal advanced breast cancer. Oncology (Huntingt) 1997; 11( 5 Suppl): 29–36.GershanovichM]]HayesDJ]]EllmanJ]]VuorinenJHigh-dose toremifene versus tamoxifen in postmenopausal advanced breast cancerOncology Huntingt19971129 54. Marttunen MB, Hietanen P, Tiitinen A, Ylikorkala O. Comparison of effects of tamoxifen and toremifene on bone biochemistry and bone mineral density in postmenopausal breast cancer patients. J Clin Endocrinol Metab 1998; 83: 1158–1162.MarttunenMB]]HietanenP]]TiitinenA]]YlikorkalaOComparison of effects of tamoxifen and toremifene on bone biochemistry and bone mineral density in postmenopausal breast cancer patientsJ Clin Endocrinol Metab1998831158 55. Saarto T, Bomqvist C Ehnholm C, Taskinen MR, Elomma I. Antiatherogenic effects of adjuvant antiestrogens: A randomized trial comparing the effects of tamoxifen and toremifene on plasma lipid levels in postmenopausal women with node-positive breast cancer. J Clin Oncol 1996; 14: 429–433.SaartoT]]BomqvistC]]EhnholmC]]TaskinenMR]]ElommaIAntiatherogenic effects of adjuvant antiestrogens: A randomized trial comparing the effects of tamoxifen and toremifene on plasma lipid levels in postmenopausal women with node-positive breast cancerJ Clin Oncol199614429 56. Tomas E, Kauppila A, Blanco G, Apaja-Sarkkinen M, Laatikainen T. Comparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patients. Gynecol Oncol 1995; 59: 261–266.TomasE]]KauppilaA]]BlancoG]]Apaja-SarkkinenM]]LaatikainenTComparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patientsGynecol Oncol199559261 57. Davies GC, Huster WJ, Plouffe L, Lakshmanan M. Adverse events reported by postmenopausal women in controlled trials with raloxifene. Obstet Gynecol 1999; 93: 558–565.DaviesGC]]HusterWJ]]PlouffeL]]LakshmananMAdverse events reported by postmenopausal women in controlled trials with raloxifeneObstet Gynecol199993558 58. Jordan VC, Glusman JE, Eckert S, et al. Raloxifene reduces incident primary breast cancer; integrated data from multicenter, double-blind, randomized trials in postmenopausal women. Presented at the 21st Annual San Antonio Breast Cancer Symposium, December 12–15, 1998, San Antonio, TX. 59. Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, et al. The effect of raloxifene on risk of breast cancer in postmenopausal women. JAMA 1999; 281: 2189–2197.CummingsSR]]EckertS]]KruegerKA]]GradyD]]PowlesTJ]]CauleyJAThe effect of raloxifene on risk of breast cancer in postmenopausal womenJAMA19992812189 60. Delmas PD, Bjarnason NH, Mitlak BH, Ravoux AC, Shah AS, Huster WJ, et al. Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med 1997; 337: 1641–1647.DelmasPD]]BjarnasonNH]]MitlakBH]]RavouxAC]]ShahAS]]HusterWJEffects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal womenN Engl J Med19973371641 61. Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial. JAMA 1999; 282: 637–645.EttingerB]]BlackDM]]MitlakBH]]KnickerbockerRK]]NickelsenT]]GenantHKReduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trialJAMA1999282637 62. Walsh BW, Kuller LH, Wild RA, Paul S, Farmer M. Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women. JAMA 1998; 279: 1445–1451.WalshBW]]KullerLH]]WildRA]]PaulS]]FarmerMEffects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal womenJAMA19982791445 63. Draper MW, Flowers DE, Huster WJ, Neild JA, Harper KD, Arnand C. A controlled trial of raloxifene HCL: Impact on bone turnover and serum lipid profile in healthy postmenopausal women. J Bone Miner Res 1996; 11: 835–862.DraperMW]]FlowersDE]]HusterWJ]]NeildJA]]HarperKD]]ArnandCA controlled trial of raloxifene HCL: Impact on bone turnover and serum lipid profile in healthy postmenopausal womenJ Bone Miner Res199611835 64. Shughrue PJ, Lane MV, Merchenthaler I. Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: An in situ hybridization study. Endocrinology 1997; 138: 5476–5484.ShughruePJ]]LaneMV]]MerchenthalerIRegulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: An in situ hybridization studyEndocrinology19971385476 65. Bryant HU, Bales KR, Paul SM, Yang H, Cole HW, Walker-Daniels J, et al. Estrogen agonist effects of selective estrogen receptor modulators in ovariectomized rat brain. Abstr Soc Neurosci 1997; 23: 2377(abstract).BryantHU]]BalesKR]]PaulSM]]YangH]]ColeHW]]Walker-DanielsJEstrogen agonist effects of selective estrogen receptor modulators in ovariectomized rat brainAbstr Soc Neurosci1997232377 66. Cyr M, Landry M, DiPaolo T. Modulation by estrogen receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain. Neuropsychopharmacology 2000; 23: 69–72.CyrM]]LandryM]]DiPaoloTModulation by estrogen receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brainNeuropsychopharmacology20002369 67. Wu X, Glinn MA, Ostrowski NL, Su Y, Ni B, Cole HW, et al. Raloxifene and estradiol benzoate both fully restore hippocampal choline acetyltransferase activity in ovariectomized rats. Brain Res 1999; 847: 98–104.WuX]]GlinnMA]]OstrowskiNL]]SuY]]NiB]]ColeHWRaloxifene and estradiol benzoate both fully restore hippocampal choline acetyltransferase activity in ovariectomized ratsBrain Res199984798 68. Nickelsen T, Lufkin EG, Riggs BL, Cox DA, Crook TH. Raloxifene hydrochloride, a selective estrogen receptor modulator: Safety assessment of effects on cognitive function and mood in postmenopausal women. Psychoneuroendocrinology 1999; 24: 115–128.NickelsenT]]LufkinEG]]RiggsBL]]CoxDA]]CrookTHRaloxifene hydrochloride, a selective estrogen receptor modulator: Safety assessment of effects on cognitive function and mood in postmenopausal womenPsychoneuroendocrinology199924115 69. Yaffe K, Krueger K, Sarkar S, Grady D, Barrett-Connor E, Cox DA, et al. Cognitive function in postmenopausal women treated with raloxifene. N Engl J Med 2001; 344: 1207–1213.YaffeK]]KruegerK]]SarkarS]]GradyD]]Barrett-ConnorE]]CoxDACognitive function in postmenopausal women treated with raloxifeneN Engl J Med20013441207 70. Boss SM, Huster WJ, Neild JA, Glant MD, Eisenhut CC, Draper MW. Effects of raloxifene hydrochloride on the endometrium of postmenopausal women. Am J Obstet Gynecol 1997; 1 77: 1458.BossSM]]HusterWJ]]NeildJA]]GlantMD]]EisenhutCC]]DraperMWEffects of raloxifene hydrochloride on the endometrium of postmenopausal womenAm J Obstet Gynecol19971771458 71. Cummings SR, Norton I, Eckert S, et al. Raloxifene reduces the risk of breast cancer and may decrease the risk of endometrial cancer in postmenopausal women: Two year findings from the Multiple Outcomes of Raloxifene Evaluation (MORE Trial). Proc Am Soc Clin Oncol 1998; 17: 2(abstract).CummingsSR]]NortonI]]EckertSRaloxifene reduces the risk of breast cancer and may decrease the risk of endometrial cancer in postmenopausal women: Two year findings from the Multiple Outcomes of Raloxifene Evaluation (MORE Trial)Proc Am Soc Clin Oncol1998172 72. Goldstein SR, Scheele WH, Rajagopalan SK, Wilkie JL, Walsh BW, Parsons AK. A 12-month comparative study of raloxifene, estrogen, and placebo on the postmenopausal endometrium. Obstet Gynecol 2000; 95: 95–103.GoldsteinSR]]ScheeleWH]]RajagopalanSK]]WilkieJL]]WalshBW]]ParsonsAKA 12-month comparative study of raloxifene, estrogen, and placebo on the postmenopausal endometriumObstet Gynecol20009595 73. Ashby J, Odum J, Foster JR. Activity of raloxifene in immature and ovariectomized rat uterotrophic assays. Regul Toxicol Pharmacol 1997; 25: 226–231.AshbyJ]]OdumJ]]FosterJRActivity of raloxifene in immature and ovariectomized rat uterotrophic assaysRegul Toxicol Pharmacol199725226 74. Rauschning W, Pritchard KI. Droloxifene a new antiestrogen: Its role in metastatic breast cancer. Breast Cancer Res Treat 1994; 31: 83–94.RauschningW]]PritchardKIDroloxifene a new antiestrogen: Its role in metastatic breast cancerBreast Cancer Res Treat19943183 75. Eppenberger U, Wosikowski K, Kung W. Pharmacologic and biologic properties of droloxifene, a new antiestrogen. Am J Clin Oncol 1991; 14( Suppl 2): S5–S14.EppenbergerU]]WosikowskiK]]KungWPharmacologic and biologic properties of droloxifene, a new antiestrogenAm J Clin Oncol199114S5 76. Ke HZ, Chen HR, Simmons HA, Qi H, Crawford DT, Pirie CM, et al. Comparative effects of droloxifene, tamoxifene and estrogen on bone, serum cholesterol and uterine histology in the ovariectomized rat model. Bone 1997; 20: 31–39.KeHZ]]ChenHR]]SimmonsHA]]QiH]]CrawfordDT]]PirieCMComparative effects of droloxifene, tamoxifene and estrogen on bone, serum cholesterol and uterine histology in the ovariectomized rat modelBone19972031 77. Herrington DM, Pusser BE, Riley WA, Thuren TY, Brosnihan KB, Brinton EA, et al. Cardiovascular effects of droloxifene. A new selective estrogen receptor modulator in healthy postmenopausal women. Arterioscler Thromb Vasc Biol 2000; 20: 1606–1612.HerringtonDM]]PusserBE]]RileyWA]]ThurenTY]]BrosnihanKB]]BrintonEACardiovascular effects of droloxifene. A new selective estrogen receptor modulator in healthy postmenopausal womenArterioscler Thromb Vasc Biol2000201606 78. Weiss S, Mulder H, Chestnut C, et al. Idoxifene reduces bone turnover in osteopenic postmenopausal women. Presented at the 80th annual meeting of the Endocrine Society, June 24–27, 1998, New Orleans, LA (abstract). 79. Bolognese M, Moffett A, Jensen C, et al. Idoxifene is well tolerated in osteopenic postmenopausal women. Presented at the ninth annual meeting of the North American Menopause Society, September 16–19, 1998, Toronto (abstract 98). 80. Toko T, Sugimoto Y, Matsuo K, Yamasaki R, Takeda S, Wierzba K, et al. TAT 59: A new triphenylethylene derivative with antitumor activity against hormone-dependent tumors. Eur J Cancer 1990; 26: 397–404.TokoT]]SugimotoY]]MatsuoK]]YamasakiR]]TakedaS]]WierzbaKTAT 59: A new triphenylethylene derivative with antitumor activity against hormone-dependent tumorsEur J Cancer199026397 81. Shibata J, Toko T, Saito H, Lykkesfeldt AE, Fujioka A, Sako K, et al. Estrogen agonistic/antagonistic effects of miproxifene phosphate (TAT 59). Cancer Chemother Pharmacol 2000; 45: 133–141.ShibataJ]]TokoT]]SaitoH]]LykkesfeldtAE]]FujiokaA]]SakoKEstrogen agonistic/antagonistic effects of miproxifene phosphate (TAT 59)Cancer Chemother Pharmacol200045133 82. Qu Q, Zheng H, Dahllund J, Laine A, Cockcroft N, Peng Z, et al. Selective estrogenic effects of a novel triphenylethylene compound FC1211a on bone, cholesterol levels, and reproductive tissues in intact and ovariectomized rats. Endocrinology 2000; 141: 809–820.QuQ]]ZhengH]]DahllundJ]]LaineA]]CockcroftN]]PengZSelective estrogenic effects of a novel triphenylethylene compound FC1211a on bone, cholesterol levels, and reproductive tissues in intact and ovariectomized ratsEndocrinology2000141809 83. Sato M, Turner CH, Wang T, Adrian MD, Rowley E, Bryant HU. LY353381.HCl: A novel raloxifene analogue with improved SERM potency and efficacy in vivo. J Pharmacol Exp Ther 1998; 287: 1–7.SatoM]]TurnerCH]]WangT]]AdrianMD]]RowleyE]]BryantHULY353381.HCl: A novel raloxifene analogue with improved SERM potency and efficacy in vivoJ Pharmacol Exp Ther19982871 84. Munster PN, Buzdar A, Dhingra K, Enas N, Ni L, Major M, et al. Phase I study of a third generation selective estrogen receptor modulator Ly353381.HCL in metastatic breast cancer. J Clin Oncol 2001; 19: 2002–2004.MunsterPN]]BuzdarA]]DhingraK]]EnasN]]NiL]]MajorMPhase I study of a third generation selective estrogen receptor modulator Ly353381.HCL in metastatic breast cancerJ Clin Oncol2001192002 &NA; When I was young, I admired clever people. Now that I am old, I admire kind people. –Abraham Heschel