Invited Commentary

Soy Products Effective in PSA in Patients with Prostate Cancer

Authors: Olivia D. Kreze, MD, PhD

Abstract

Prostate cancer is the leading cause of cancer and second leading cause of death among men.1 Soy has been explored for an association to prostate cancer based on the observation that men in Asia have lower rates of prostate cancer and consume higher amounts of soy. So far, there have been no conclusive data showing that soy can offer protection against progression of prostate cancer. However, several small retrospective studies have shown that some protection may be gained.2 A Japanese study conducted at Sapporo Medical University School of Medicine, Japan, demonstrated that isoflavones significantly decreased the risk of prostate cancer and concluded that isoflavones might be an effective dietary protective factor against prostate cancer in Japanese men. The scientists came to this conclusion after examining the associations between nutritional and other lifestyle factors and the prevalence of prostate cancer in a case-control study of Japanese men.

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References

1. Saad F, Hotte SJ. Guidelines for the management of castrate-resistant prostate cancer. Can Urol Assoc J 2010;4:380-384.
 
2. Kurahashi N, Iwasaki M, Sasazuki S, et al. Soy product and isoflavone consumption in relation to prostate cancer in Japanese men. Cancer Epidemiol Biomarkers Prev 2007;16:538-545.
 
3. Moul JW, Banez LL, Freedland SJ. Rising PSA in nonmestastatic prostate cancer. Oncology2007;21:12.
 
4. Joshi M, Agostino NM, Gingrich R, et al. Effects of commercially available soy products on PSA in androgen-deprivation-naïve and castration-resistant prostate cancer. South Med J 2011;104:736-740.