Case Report
Spontaneous Cholesterol Crystal Embolization to Bone Marrow
Abstract
Cholesterol crystal embolization is a well-established complication of arterial trauma and anticoagulation which may involve multiple organs including the skin and muscle, producing clinical features such as livedo reticularis, cyanosis and gangrene of the toes and intense myalgias. Cholesterol crystal embolization to bone marrow has been described in postmortem studies, but has been previously reported premortem in only two patients, both of whom had characteristic risk factors and clinical features. We report herein a case of spontaneous cholesterol crystal embolization to bone marrow in a patient with atypical clinical manifestations.
Key Points
* Cholesterol crystal embolization may occur following arterial trauma or anticoagulation.
* Spontaneous cholesterol crystal embolization has been reported.
* The clinical features of cholesterol crystal embolization reflect sites of embolization such as skin and muscle.
* Cholesterol crystal embolization to bone marrow has been reported premortem twice before in patients with characteristic clinical features.
* To our knowledge, this is the first reported case of cholesterol crystal embolization to bone marrow diagnosed premortem in a patient with an atypical clinical presentation.
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