Letter to the Editor
Tadalafil and Palpebral Edema
Abstract
Tadalafil is a selective and reversible type 5 phosphodiesterase (5PDE) inhibitor. Therefore, its effect is greater on 5PDE than on other phosphodiesterases. It is indicated in the treatment of erectile dysfunction but still requires sexual stimulation to be effective. Tadalafil has a longer elimination half-life than sildenafil (17.5 versus 3.7 hours, respectively) and provides an efficient erection up to 36 hours after ingestion of the drug. To our knowledge, only rare and short-lasting side effects have been reported, most frequently headaches, dyspepsia, dizzy spells, hot flushes, blocked nose, back and muscle pain, and, more rarely, eye pain, conjunctival hyperemia, and eyelid edema.1 To the best of our knowledge, this is the first case of palpebral edema probably related to the ingestion of tadalafil.This content is limited to qualifying members.
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