Rapid Response

Topiramate for Treatment of Alcohol Dependence

Authors: John B. Standridge, Alexander P. Zotos

Abstract

Topiramate for Treatment of Alcohol Dependence


Alcoholism is the third leading cause of preventable mortality and morbidity in the United States. Johnson et al have shown that topiramate can improve drinking outcomes among alcohol-dependent individuals. The mechanism is the latest in a series of efforts to translate the developing neuroscience of addiction into clinically beneficial interventions. The topiramate intervention offers real promise for a devastating disease that badly needs effective treatment measures.

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