Letter to the Editor

Vitamin D Deficiency in Primary Aldosteronism*

Authors: Dung Ngoc Pham Nguyen, MD, Lan Thi Hoang Nguyen, MD, Khanh vinh quoc Luong, MD

Abstract

Alterations in calcium metabolism have been reported in hypertensive patients and animal models. However, there is no report on the presence of vitamin D deficiency in salt-sensitive hypertension of primary aldosteronism in the literature. We report a patient who presented with primary aldosteronism associated with vitamin D deficiency. We discuss the relationship between vitamin D deficiency and salt-sensitive hypertension of primary aldosteronism.

This content is limited to qualifying members.

Existing members, please login first

If you have an existing account please login now to access this article or view purchase options.

Purchase only this article ($25)

Create a free account, then purchase this article to download or access it online for 24 hours.

Purchase an SMJ online subscription ($75)

Create a free account, then purchase a subscription to get complete access to all articles for a full year.

Purchase a membership plan (fees vary)

Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

References

1. McCarron DA, Pingree PA, Rubin RJ, et al. Enhanced parathyroid function in essentialhypertension: a homeostatic response to a urinary calcium leak. Hypertension 1980;2:162–168.
 
2. Resnick LM, Muller FB, Laragh JH. Calcium-regulating hormones in essential hypertension: relation to plasma renin activity and sodium metabolism. Ann Intern Med 1986;105:649–654.
 
3. Reichel H, Liebethal R, Hense HW, et al. Disturbed calcium metabolism in subjects with elevated diastolic blood pressure. Clin Investig 1992;70:748–751.
 
4. McCarron DA, Yung NN, Ugoretz BA, et al. Disturbances of calcium metabolism in the spontaneously hypertensive rat. Hypertension 1981;3:I162–I167.
 
5. Kotchen TA, Ott CE, Whitescarver SA, et al. Calcium, parathyroid hormone, and vitamin D in the ‘prehypertensive’ Dahl salt-sensitive rat. Am J Hypertens 1990; 3: 167S–170S.
 
6. Clements MR, Johnson L, Fraser DR. A new mechanism for induced vitamin D deficiency in calcium deprivation. Nature 1987;325:62–65.
 
7. Thierry-Palmer M, Doherty A, Bayorh MA, et al. Dahl salt-sensitive rats excrete 25-hydroxyvitamin D into urine. J Nutr 2003;133:187–190.
 
8. Bell NH, Greene A, Epstein S, et al. Evidence for alteration of the vitamin D-endocrine system in blacks. J Clin Invest 1985;76:470–473.