SMJ Article | Review Article

Aprocitentan: A New Option for Resistant Hypertension and Its Place in Patient Care

Hypertension affects approximately 47.7% of US adults, with higher rates observed in men (50.8%) compared with women (44.6%). Risk factors and characteristics such as age, family history, race, and ethnicity also can increase the risk of developing high blood pressure and can make treatment more difficult. Aprocitentan is the first...

Posted in: Hypertension11

May 17, 2026

May 17 is World Hypertension Day

On May 17, the Southern Medical Association (SMA) joins the global community in observing World Hypertension Day.

Posted in: Hypertension2

SMJ Article | Review Article

Therapeutic Approach to Heart Failure Management: Insight from Clinical Trials

Heart failure (HF) is a global burden and, irrespective of age, sex, race, nationality, and geography, affects individuals across the world. Several reports mentioned that, globally, more than 64 million people, which accounts for 1% to 3% of the total global population, are living with HF. In the United States,...

Posted in: Cardiovascular Disease34

SMJ Article | Original Article

Publication Bias in Coronary Artery Disease Clinical Trials: A Bibliometric Review

Objective: The objective of our study was to determine the extent of publication bias of clinical trials pertaining to the treatment of coronary artery disease. Specifically, studies are more likely to be published if the results are positive and have a higher citation rate. Methods: The US National Library of...

Posted in: Cardiovascular Disease34

SMJ Article | Original Article

Heart Disease Mortality on the Mississippi River

Objectives: States bordering the lower Mississippi River have large Black populations totaling 1,996,897. In 2019, 7506 Blacks there died of heart disease. These four states have high heart disease death rates. This analysis examined geographic variation in heart disease to suggest populations to target for intervention and suggest hypotheses for...

Posted in: Cardiovascular Disease34

SMJ Article | Original Article

Surgical Treatment of Cardiac Tumors: A Single-Center Experience

Objectives: Cardiac tumors affect fewer than 1 in 2000 people. This study is a retrospective review of diagnostic procedures, surgical management, and outcomes in patients treated for tumors of the heart at our institution. We compare our management approaches, clinical, and surgical outcomes with those reported in the literature. Methods:...

Posted in: Cardiac Tumors1

SMJ Article | Review Article

Role of hs-CRP in Post-MI Sequelae: Insights into Mechanisms and Clinical Significance

High-sensitivity C-reactive protein (hs-CRP) is a key marker of inflammation, predominantly produced by hepatocytes and various tissues, including intracardiac tissue, atherosclerotic plaques, and vascular smooth muscles. The biomarker serves as a crucial element of innate immunity and rises in response to various disease processes, including infections and cancers. This rise...

Posted in: Cardiovascular Disease34

SMJ Article | Original Article

Complementary and Alternative Medicine Use among Heart Failure Patients in the Deep South

Objective: Despite advancements in heart failure (HF) diagnostics and treatment, many palliative care patients with HF often seek complementary and alternative medicine (CAM) to improve quality of life and address unmet physical and emotional needs. This study aimed to explore the prevalence and patterns of CAM use among HF patients...

Posted in: Cardiovascular Disease34

SMJ Article | Review Article

The Moreton Lecture Series: The Renin-Angiotensin-Aldosterone System—Physiology, Pathophysiology, and Pharmacological Inhibition

The renin-angiotensin-aldosterone system (RAAS) is a complex regulator comprising hormones, proteins, and enzymes. The discovery of the RAAS and its pharmacological manipulation has been essential in the management of cardiovascular diseases, including hypertension. Beyond the benefits of hypertension, RAAS inhibition has implications for heart failure, atherosclerotic disease, and kidney disease....

Posted in: Hypertension11

SMJ Article | Original Article

Management of Pulmonary Embolism: A Single-Center Experience

Objective: Pulmonary embolism (PE) is the third leading cause of cardiovascular death. The objective of this study was to examine the current management of pulmonary embolism at a single academic institution. Methods: With institutional review board approval, we conducted a retrospective chart review of 805 encounters among 775 patients presenting...

Posted in: Cardiovascular Disease34

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