Abstract | November 18, 2023

Cocaine-induced Ascending Aortic Thrombus

Prutha Rohit Pathak, MBBS, MPH, Internal Medicine Resident PGY-1, North Alabama Medical Center, Florence, AL

Siddharth Patel, MBBS,MPH, Hospitalist/Internal medicine, Decatur Morgan Hospital, Decatur, AL; Ashish Basu, MD, Cardiologist/Cardiology, Heart Center, Decatur, AL

Learning Objectives

  1. Identify the unique vascular complications of consistent cocaine use
  2. Highlight the importance of early recognition and management of life threatening complications of regular cocaine use

Introduction:
Ascending aortic thrombus in a non-aneurysmal, non-atherosclerotic aorta is an uncommon occurrence. Although arterial thrombosis has been linked with the use of cocaine, thrombus formation particularly in the ascending aorta has rarely been described.

Case Presentation
We report a young man with regular cocaine use presenting with chest pain.

Final/Working Diagnosis
He was found to have a large thrombus in a structurally normal ascending aorta.

Management/Outcome/ and or Follow-up
Medical management with therapeutic anticoagulation was started. The patient survived despite the interruption of anticoagulation treatment for three months due to non-compliance. This unique case highlights the importance of knowledge of various vascular complications associated with cocaine use, its early recognition, and treatment.

References and Resources

  1. Paulin Vera CM, Mateos Colin A, Calvo Arrojo G, Colodro García JM. Acute aortoiliac thrombosis due to cocaine intake. Ann Vasc Surg. 2013;27(2):239.e1-239.e2394. doi:10.1016/j.avsg.2012.06.013
  2. Fayad ZY, Semaan E, Fahoum B, Briggs M, Tortolani A, D’Ayala M. Aortic mural thrombus in the normal or minimally atherosclerotic aorta. Ann Vasc Surg. 2013;27(3):282-290. doi:10.1016/j.avsg.2012.03.011
  3. Chen YY, Yen HT, Wu CC, Huang KR, Sheu JJ, Lee FY. Aortic Thrombus in a Nonaneurysmal Ascending Aorta. Ann Vasc Surg. 2021;72:617-626. doi:10.1016/j.avsg.2020.10.031
  4. Khine K, Toor A, Khalighi K, Krishnamurthy M. Incidental descending thoracic aortic thrombus: the conundrum of medical versus surgical therapy. J Community Hosp Intern Med Perspect. 2019;9(6):491-494. Published 2019 Dec 14. doi:10.1080/20009666.2019.1684230
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