Invited Commentary
Commentary on “Tiotropium in the Treatment of Patients with Asthma”
Neural control of the airways occurs almost exclusively through the vagal nerve, and activation of this cholinergic system results in bronchoconstriction and mucus hypersecretion. The primary transmitter, acetylcholine, released from prejunctional parasympathetic synapses, acts upon muscarinic receptors, of which five distinct subtypes have been identified (M1-M5). Three of these subtypes…