SMJ // November 2020, Volume 113 - Issue 11

Original Article

A Game Show–Based Curriculum for Teaching Principles of Reproductive Infectious Disease (GBS PRIDE Trial)

Objectives: The purpose of this study was to evaluate whether a game show–based curriculum improves obstetrics and gynecology (OBGYN) residents’ confidence in and understanding of the principles of reproductive infectious disease (RID), clinical manifestations and sequelae of sexually transmitted infection (STI), and management of serious long-term consequences of STIs. Methods:…

Posted in: Sexually Transmitted Diseases & Infections of Reproductive Organs2

Perspectives

From Bench to Every Bedside: Improving the Adoption of Evidence-Based Practices

The medical research industry in the United States is impressive, with more than 119 billion spent annually on biomedical research and development, including discoveries of effective treatments, diagnostic tests, and procedures.1 These discoveries are meaningless, however, unless they are effectively implemented into routine clinical practice. The often-repeated paradigm of translational…

Original Article

Evidence for Cancer Literacy Knowledge Retention among Kentucky Middle and High School Students after a Brief Educational Intervention

Objectives: Although cancer is seen in every state in the United States, it does not affect every geographic area and population equally. Kentucky has the highest cancer incidence and mortality rates in the country, with an unusually high number of cases localized in its Appalachian region. Risk factors such as…

Posted in: Medical Oncology37

Review Article

Gynecological Care and Contraception Considerations in Women with Cerebral Palsy

The purpose of this literature review was to further explore gynecological care and contraceptive use in women with cerebral palsy. We address barriers to pelvic examinations for cervical cancer screenings and current contraceptive methods in severely debilitated patients with cerebral palsy.

Posted in: Neurology16 Obstetrics and Gynecology45

Original Article

Prevention of Neonatal Abstinence Syndrome in an Outpatient Prenatal Buprenorphine Tapering Program

Objectives: Many addicted pregnant patients receiving buprenorphine medication-assisted therapy (MAT) wish to discontinue this medication while pregnant. This study was undertaken to determine whether outpatient detoxification from buprenorphine during pregnancy is safe and effective when confirmed with postdetoxification urine drug screens (UDSs). Methods: This case series reports the maternal and…

Posted in: Pregnancy32

Original Article

Less Toxic Chemotherapy in Locally Advanced Breast Cancer

Objectives: Preoperative chemotherapy produces tumor shrinkage in most patients with locally advanced breast cancer, including some pathological complete responses (pCRs). We attempted this using a much less toxic sequential regimen, given with concurrent bevacizumab. Methods: Patients with locally advanced breast cancer received 3 intravenous doses each of preoperative sequential liposome…

Posted in: Medical Oncology37 Breast Cancer4

Original Article

CME Article: Factors Affecting Patient Adherence to Lung Cancer Screening

Objectives: The National Lung Screening Trial (NLST) demonstrated a 20% reduction in mortality with low-dose computed tomography (CT) for lung cancer screening (LCS). The NLST found the greatest benefit to LCS for patients who underwent annual screening for a full 3-year follow-up period. The adherence to serial imaging in the…

Posted in: Medical Oncology37

Original Article

Impact of Obesity in Hospitalized Patients with Heart Failure: A Nationwide Cohort Study

Objectives: Obesity and cardiovascular disease remain significant burdens on the overall provision of health care in the United States. Obesity has been shown to be a direct risk factor for heart failure (HF). We conducted a nationwide cohort study to assess the short-term impact of obesity in hospitalized patients with…

Posted in: Cardiovascular Disease24

Original Article

Cognitive Tests and Stool Frequency at Hospital Discharge Do Not Predict Outcomes in Hepatic Encephalopathy

Objectives: Hepatic encephalopathy (HE) is associated with hospital readmissions and mortality. We sought to determine whether cognitive testing and stool frequency at discharge predicted 30-day readmission or death in cirrhotic patients admitted with overt HE. Methods: We approached consecutive inpatients with cirrhosis and overt HE when they were within 48…

Posted in: Gastroenterology43 Liver Disease8

Review Article

Evolving Approaches to Antithrombotics in Stroke Prevention and Treatment

The optimization of antithrombotic therapy for acute stroke treatment and secondary prevention is an evolving process based on an increasing array of studies that provide an evidence-based approach. Options have increased dramatically with the release of the non–vitamin K oral anticoagulants and with the results of recent randomized clinical trials…

Posted in: Neurology16

Original Article

Outcomes of Clostridioides difficile in Patients with Vitamin D Deficiency: A Propensity-Matched National Inpatient Sample Analysis

Objectives: We aimed to determine in-hospital outcomes, length of hospital stay, and resource utilization in a contemporary cohort of Clostridioides difficile infection (CDI) and vitamin D deficiency (VDD). Methods: The National Inpatient Sample database for 2016 and 2017 was used for data analysis using International Classification of Diseases, Tenth Revision,…

Posted in: Infectious Disease136

Review Article

OPEN: Immune Checkpoint Inhibitor-Related Pulmonary Toxicity: Focus on Nivolumab

The development of checkpoint inhibitors has changed the treatment paradigm for cancer. Checkpoint inhibitors nivolumab, pembrolizumab, and cemiplimab target programmed death-1 (PD-1), whereas durvalumab, avelumab, and atezolizumab target PD-ligand 1. Ipilimumab targets cytotoxic T lymphocyte–associated antigen 4. Used as monotherapy or in combination, these inhibitors have shown remarkable efficacy in…

Posted in: Pulmonary Disease16
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