SMJ // Pulmonary Disease

SMJ Article | Review Article

Pathophysiology and Management of Neurogenic Pulmonary Edema in Patients with Acute Severe Brain Injury

Acute brain injury (ABI) consists of any acquired insult to the brain and is a significant cause of morbidity and mortality worldwide. Approximately 20% to 30% of patients with ABI develop a lung injury called neurogenic pulmonary edema (NPE), and its development often results in poor outcomes. This article provides...

Posted in: Acute Respiratory Distress Syndrome (Ards)1

SMJ Article | Original Article

Annual FEV1 Loss in Patients with Noncystic Fibrosis Bronchiectasis and Affecting Factors

Objectives: Bronchiectasis is a chronic respiratory disease characterized by sputum production, cough, and several bronchial infections. Lung function is an important parameter to evaluate and study in patients with bronchiectasis. This study aimed to evaluate the annual changes in forced expiratory volume in one second (FEV1) and related factors in...

Posted in: Pulmonary Disease13

SMJ Article | Errata

Clinical Outcomes of Noninvasive Ventilation in Asthma, Bronchiectasis, and Other COPD: Erratum

In the February 2021 issue of Southern Medical Journal, in the article by Nemeh et al, “Clinical Outcomes of Noninvasive Ventilation in Asthma, Bronchiectasis, and Other COPD”, the third author’s last name was misspelled. The author’s name should have appeared as Emmanuella Oduguwa.

Posted in: Pulmonary Disease13

SMJ Article | Review Article

OPEN: An Epidemic Supplanted by a Pandemic: Vaping-Related Illness and COVID-19

Before the coronavirus disease 2019 (COVID-19) pandemic, vaping-related illness was the prevailing public health concern. The incidence of vaping-related illnesses—mainly e-cigarette, or vaping, product use–associated lung injury (EVALI)—went from a peak in September 2019 to a low in February 2020, and the Centers for Disease Control and Prevention decided to...

Posted in: Infectious Disease117 Pulmonary Disease13

SMJ Article | Original Article

CME Article: Clinical Outcomes of Noninvasive Ventilation in Asthma, Bronchiectasis, and Other COPD

Objectives: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and disability worldwide. Use of noninvasive ventilation (NIV) appears to be associated with a significant decrease in frequency of exacerbation, hospital admissions, and mortality in patients with COPD. In this study, we sought to determine clinical outcomes, prevalence,...

Posted in: Pulmonary Disease13

SMJ Article | Perspectives

Oxygen Supplementation in COPD Exacerbation with Hypoxia and Hypercapnia: What Does the Evidence Show?

Chronic obstructive pulmonary disease (COPD) is projected to be the third leading cause of mortality worldwide in 2020, with an annual healthcare expenditure of $50 billion in the United States alone.1,2 Acute exacerbation of COPD (AECOPD), characterized by worsening cough, sputum production, and breathlessness (beyond day-to-day variation), is frequently associated...

Posted in: Infectious Disease117 Pulmonary Disease13

SMJ Article | Original Article

Association between Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and Lung Cancer

Objectives: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are the most commonly prescribed antihypertensives, with prior studies identifying a possible association between long-term use and increased rates of lung cancer. This study evaluated this potential association in a large population using propensity matching. Methods: This was a population-based...

Posted in: Lung Cancer1

SMJ Article | Original Article

Outcomes of Idiopathic Pulmonary Fibrosis Improve with Obesity: A Rural Appalachian Experience

Objectives: Obesity can be an independent predictor of fibrosis in tissues, including the liver, heart, and skin. We evaluated a rural Appalachian cohort of idiopathic pulmonary fibrosis (IPF) for its relation to obesity. Methods: Using American Thoracic Society 2018 diagnostic guidelines, an IPF cohort was systematically identified at an Appalachian...

Posted in: Pulmonary Disease13

SMJ Article | Review Article

OPEN: Immune Checkpoint Inhibitor-Related Pulmonary Toxicity: Focus on Nivolumab

The development of checkpoint inhibitors has changed the treatment paradigm for cancer. Checkpoint inhibitors nivolumab, pembrolizumab, and cemiplimab target programmed death-1 (PD-1), whereas durvalumab, avelumab, and atezolizumab target PD-ligand 1. Ipilimumab targets cytotoxic T lymphocyte–associated antigen 4. Used as monotherapy or in combination, these inhibitors have shown remarkable efficacy in...

Posted in: Pulmonary Disease13

SMJ Article | Editorial

Cystic Fibrosis and COVID-19

In the early days of the coronavirus disease 2019 (COVID-19) pandemic, most of the specialists caring for patients with cystic fibrosis (CF) feared for the worst while waiting for more evidence to better characterize the natural history of the disease. Any emerging pathogen could spell trouble for patients with chronic...

Posted in: Pulmonary Disease13

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