Specialties - Southern Medical Association

SMJ Article | Review Article

OPEN: Immune Checkpoint Inhibitor-Related Pulmonary Toxicity: Focus on Nivolumab

The development of checkpoint inhibitors has changed the treatment paradigm for cancer. Checkpoint inhibitors nivolumab, pembrolizumab, and cemiplimab target programmed death-1 (PD-1), whereas durvalumab, avelumab, and atezolizumab target PD-ligand 1. Ipilimumab targets cytotoxic T lymphocyte–associated antigen 4. Used as monotherapy or in combination, these inhibitors have shown remarkable efficacy in...

Posted in: Pulmonary Disease5

SMJ Article | Editorial

Cystic Fibrosis and COVID-19

In the early days of the coronavirus disease 2019 (COVID-19) pandemic, most of the specialists caring for patients with cystic fibrosis (CF) feared for the worst while waiting for more evidence to better characterize the natural history of the disease. Any emerging pathogen could spell trouble for patients with chronic...

Posted in: Pulmonary Disease5

SMJ Article | Original Article

Prevalence and Clinical Impact of Atrial Fibrillation in Patients with Pulmonary Embolism

Objectives: Atrial fibrillation (AF) has been suggested as a cause for pulmonary embolism (PE). We aimed to explore the prevalence and clinical impact of AF in patients with PE.Methods: Using the 2012–2014 National (Nationwide) Inpatient Sample database, we identified “adult patients with PE” as the principal discharge diagnosis. The identified...

Posted in: Miscellaneous Cardiovascular Disease (Physical Examination Findings, Murmurs)2 Miscellaneous Pulmonary Disorders (Indications for Spirometry)2

SMJ Article | Original Article

Frequency of β-Blocker Use Following Exacerbations of COPD in Patients with Compelling Indication for Use

Objective: To assess the current use of β-blockers in patients with compelling indications for use, following the acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods: We performed a multicenter retrospective observational study using data from all of the patients admitted to five institutions for an acute exacerbation of COPD. Patients...

Posted in: Pulmonary Disease5

SMJ Article | Original Article

Prevalence and Predictors of Pulmonary Embolism in Hospitalized Patients with Syncope

Objectives: Approximately one in six patients hospitalized with syncope have pulmonary embolism (PE), according to the PE in Syncope Italian Trial study. Subsequent studies using administrative data have reported a PE prevalence of <3%. The aim of the study was to determine the prevalence and predictors of PE in hospitalized...

Posted in: Miscellaneous Pulmonary Disorders (Indications for Spirometry)2