Breast Cancer

SMJ Article | Multidisciplinary Clinical Case Study

Two Cases of Mistaken Identity: Neuroendocrine Tumors for Primary or Metastatic Breast Cancer

There are similarities between neuroendocrine tumors (NET) and primary breast cancers. A misdiagnosis can significantly affect prognosis and patient treatment plans, leading to potential catastrophic effects on patient care. In this study, we look at two cases in which NET was misdiagnosed as a primary breast cancer, in the breast...

Posted in: Breast Cancer13

SMJ Article | Original Article

Does the Number of Positive Nodes in pN1 Premenopausal HR+/HER2− Breast Cancer Patients with a Low 21-Gene Recurrence Score Predict Chemotherapy Benefit?

Objectives: The RxPONDER trial showed premenopausal patients with pT1-2 N1 hormone receptor-positive (HR+)/HER2− breast cancer benefit from chemotherapy regardless of 21-gene recurrence score (RS), but it did not analyze whether the number of positive lymph nodes (+LNs) was correlative of outcomes. Our study sought to evaluate whether the number of...

Posted in: Breast Cancer13

SMJ Article | Original Article

A Silver Lining for Massive Weight Loss Patients with Breast Cancer: A Propensity-Matched Analysis Comparing Abdominal Outcomes after DIEP and Abdominoplasty

Objectives: Patients with a history of massive weight loss (MWL) frequently undergo body-contouring surgery such as abdominoplasty, and the safety profile of this procedure is well accepted. The deep inferior epigastric artery perforator (DIEP) flap is a procedure where excess abdominal tissue is used to reconstruct the breast. The abdominal...

Posted in: Breast Cancer13

SMJ Article | Original Article

Prevalence of Germline Mutations among Young Women with Breast Cancer in Louisiana by Cancer Subtype and Race

Objective: Black women in Louisiana have an increased breast cancer incidence. In addition, mortality and incidence of breast cancer in younger patients are on the rise, regardless of race or germline mutations. Most available germline mutation data in breast cancer are based primarily on White patient populations. We sought to...

Posted in: Breast Cancer13

SMJ Article | Original Article

Premalignant Colorectal Adenoma Detection in Individuals with Inherited CDH1 Genetic Mutations: A Single-Institution Experience

Objectives: Pathogenic germline CDH1 variants result in increased risk of gastric (GC) and invasive lobular (ILC) carcinomas with high penetrance. Limited data suggest a higher incidence of colorectal neoplasia in carriers of CDH1 mutations, but data remain limited on the risk of colorectal adenoma formation and the role of colonoscopy...

Posted in: Breast Cancer13

SMJ Article | Original Article

Identifying Axillary Metastases in Patients with T3 Invasive Lobular Carcinoma

Objectives: Axillary lymph node (ALN) metastases are difficult to diagnose in invasive lobular carcinoma (ILC). This study evaluated the use of axillary ultrasound (AUS) and magnetic resonance imaging (MRI) in predicting ALN metastases in patients with ILC tumors >5 cm, who are at high risk of axillary metastases. Methods: This...

Posted in: Breast Cancer13

SMJ Article | Original Article

Factors Associated with Positive Margin Requiring Re-Excision after Oncoplastic Breast-Conserving Surgery

Objective: Multiple factors are associated with re-excision after breast-conserving surgery (BCS), however there is minimal literature discussing factors associated with re-excision after oncoplastic BCS (OBCS). This retrospective study aimed to identify factors associated with positive margins requiring re-excision after OBCS. Methods: A retrospective review was performed on patients who underwent...

Posted in: Breast Cancer13

SMJ Article | Original Article

Molecular Subtypes and Radiotherapy as Determinants of Survival in Invasive Breast Cancer: Insights from a Single-Center Study

Objectives: Invasive breast cancer (IBC) is a heterogeneous disease, with molecular subtypes guiding treatment and prognosis. Radiotherapy, a key component of breast cancer therapy, may vary in efficacy across subtypes. This study assessed the distribution of molecular subtypes and the use of radiotherapy, as well as their associations with clinicopathological...

Posted in: Breast Cancer13

SMJ Article | Editorial

Multidisciplinary Insights into the Complexities of Breast Cancer

Breast cancer care is advancing at an extraordinary pace, yet each new answer seems to raise fresh questions for clinicians, researchers, and patients alike. With that dynamic landscape in mind, the Southern Medical Journal devotes this special issue to the latest insights across the continuum of breast cancer diagnosis, treatment,...

Posted in: Breast Cancer13

SMJ Article | Special Section

Introduction to Special Issue on Breast Cancer

Breast cancer is the most common cancer next to skin cancer for women in the United States, and it is the second leading cause of cancer death after lung cancer. New cases of female breast cancer rose an average of 0.6% each year between 2013 and 2022. Fortunately, the death...

Posted in: Breast Cancer13

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