Case Report

Pulmonary Aspergillosis and Central Nervous System Hemorrhage as Complications of Autoimmune Hemolytic Anemia Treated with Corticosteroids

Authors: Dennis J. Cleri, MD, FACP, FAAM, FIDSA, Robert L. Moser, MD, FACP, Francisco J. Villota, MD, Yue Wang, MD, Syed A. Husain, MD, Shahzinah Nadeem, MD, Tarek Anjari, MD, Mohammad Sajed, MD

Abstract

Warm, active antibody adult autoimmune hemolytic anemia is the most common form of hemolytic anemia not related to drug therapy. Mortality in adult autoimmune hemolytic anemia is related to the inability to successfully treat patients’ underlying disease, or the infectious complications of splenectomy and prolonged steroid therapy. Predisposing factors for invasive aspergillosis are neutropenia and steroid therapy. We present a fatal case of aspergillosis complicating a nonneutropenic case of warm active antibody adult autoimmune hemolytic anemia treated with prolonged steroid therapy.

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