Abstract
Objectives:To determine the predominant pulmonary function abnormality in overweight and moderately obese subjects and to evaluate the correlation between the severity of lung function impairment and the degree of obesity.Methods:Fifty-three volunteers underwent physical examination, skin fold measurements, and standardized pulmonary function tests. Thirty-one women and 22 men with a mean age of 40.2 (18–66) years were studied.Results:The reduction in functional residual capacity (FRC) and expiratory reserve volume (ERV) were the most common abnormalities in overweight and obese subjects. The reduction in static lung volume was correlated with the degree of obesity in women and men. Stepwise multiple regression coefficients were obtained separately for women and men. Subscapular skinfold was the best predictor in women for FRC and waist-to-hip ratio (WHR) and BMI were found the best for ERV. WHR was found predictive for forced vital capacity, total lung capacity, and FRC in men.Conclusions:The lung volumes are substantially affected in our overweight and obese subjects. This influence is focused on different parameters of respiratory functions in men and women in relation to body fat distribution.
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References
References1. Sue DY. Obesity and pulmonary function: more or less? Chest 1997;111:844–845.SueDYObesity and pulmonary function: more or less?Chest1997111844-8452. Bray GA. Complications of obesity. Ann Intern Med 1985;103:1052–1062.BrayGAComplications of obesity.Ann Intern Med19851031052-10623. Akbay E, Buğdaycı R, Tezcan H, et al. The prevalence of obesity in adult population in a city on the Mediterranean coast of Turkey. Turkish J Endocrinol Metab 2003;1:31–35.AkbayE]]BuğdaycıR]]TezcanH&etal;The prevalence of obesity in adult population in a city on the Mediterranean coast of Turkey.Turkish J Endocrinol Metab2003131-354. Lazarus R, Gore CJ, Booth M, et al. Effects of body composition and fat distribution on ventilatory function in adults. Am J Clin Nutr 1998;68:35–41.LazarusR]]GoreCJ]]BoothM&etal;Effects of body composition and fat distribution on ventilatory function in adults.Am J Clin Nutr19986835-415. Jebb SA. Measuring body composition: from the laboratory to the clinic, in Kopelman PG, Stoch M (eds): Clinical Obesity. Oxford, Blackwell science, 1998, pp 18–49.JebbSAMeasuring body composition: from the laboratory to the clinic, in Kopelman PG, Stoch M (eds): Clinical Obesity.OxfordBlackwell science199818-496. Jones RL, Nzekwu MM. The effects of body mass index on lung volumes. Chest 2006;130:827–833.JonesRL]]NzekwuMMThe effects of body mass index on lung volumes.Chest2006130827-8337. Chen Y, Rennie D, Cormier YF, et al. Waist circumference is associated with pulmonary function in normal-weight, overweight, and obese subjects. Am J Clin Nutr 2007;85:35–39.ChenY]]RennieD]]CormierYF&etal;Waist circumference is associated with pulmonary function in normal-weight, overweight, and obese subjects.Am J Clin Nutr20078535-398. Lazarus R, Sparrow D, Weiss ST. Effects of obesity and fat distribution on ventilatory function: the normative aging study. Chest 1997;111:891–898.LazarusR]]SparrowD]]WeissSTEffects of obesity and fat distribution on ventilatory function: the normative aging study.Chest1997111891-8989. Harik-Khan RI, Wise RA, Fleg JL. The effect of gender on the relationship between body fat distribution and lung function. J Clin Epidemiol 2001;54:399–406.Harik-KhanRI]]WiseRA]]FlegJLThe effect of gender on the relationship between body fat distribution and lung function.J Clin Epidemiol200154399-40610. Collins LC, Hoberty PD, Walker JF, et al. The effect of body fat distribution on pulmonary function tests. Chest 1995;107:1298–1302.CollinsLC]]HobertyPD]]WalkerJF&etal;The effect of body fat distribution on pulmonary function tests.Chest19951071298-130211. Wise RA, Enright PL, Connett JE, et al. Effect of weight gain on pulmonary function after smoking cessation in the Lung Health Study. Am J Respir Crit Care Med 1998;157:866–872.WiseRA]]EnrightPL]]ConnettJE&etal;Effect of weight gain on pulmonary function after smoking cessation in the Lung Health Study.Am J Respir Crit Care Med1998157866-87212. WHO Consultation on Obesity. Preventing and Managing the Global Epidemic. Geneva, World Health organization, 1997, pp 1–276.WHO Consultation on ObesityPreventing and Managing the Global Epidemic.GenevaWorld Health organization19971-27613. Standardization of Spirometry, 1994 Update. American Thoracic Society. Am J Respir Crit Care Med 1995;152:1107–1136.&NA;Standardization of Spirometry, 1994 Update. American Thoracic Society.Am J Respir Crit Care Med19951521107-113614. Quanjer PH, Tammeling GJ, Cotes JE, et al. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993;16:5–40.QuanjerPH]]TammelingGJ]]CotesJE&etal;Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society.Eur Respir J Suppl1993165-4015. Jenkins SC, Moxham J. The effects of mild obesity on lung function. Respir Med 1991;85:309–311.JenkinsSC]]MoxhamJThe effects of mild obesity on lung function.Respir Med199185309-31116. Martinez Guerra ML, Fernandez Bonetti P, Sandoval Zarate J, et al. Arteriovenous shunting in obesity, its relation to lung volume. Arch Inst Cardiol Mex 1981;51:365–370.Martinez GuerraML]]Fernandez BonettiP]]Sandoval ZarateJ&etal;Arteriovenous shunting in obesity, its relation to lung volume.Arch Inst Cardiol Mex198151365-37017. Prefaut C, Ramonatxo M, Monnier L, et al. Mechanical effects of obesity on lung function. Pathol Biol 1980;28:149–154.PrefautC]]RamonatxoM]]MonnierL&etal;Mechanical effects of obesity on lung function.Pathol Biol198028149-15418. Chen Y, Horne SL, Dosman JA. Body weight and weight gain related to pulmonary function decline in adults: a six year follow up study. Thorax 1993;48:375–380.ChenY]]HorneSL]]DosmanJABody weight and weight gain related to pulmonary function decline in adults: a six year follow up study.Thorax199348375-38019. Ray CS, Sue DY, Bray G, et al. Effects of obesity on respiratory function. Am Rev Respir Dis 1983;128:501–506.RayCS]]SueDY]]BrayG&etal;Effects of obesity on respiratory function.Am Rev Respir Dis1983128501-50620. Rubinstein I, Zamel N, DuBarry L, et al. Airflow limitation in morbidly obese, nonsmoking men. Ann Intern Med 1990;112:828–832.RubinsteinI]]ZamelN]]DuBarryL&etal;Airflow limitation in morbidly obese, nonsmoking men.Ann Intern Med1990112828-83221. Canoy D, Luben R, Welch A, et al. Abdominal obesity and respiratory function in men and women in the EPIC-Norfolk Study, United Kingdom. Am J Epidemiol 2004;159:1140–1149.CanoyD]]LubenR]]WelchA&etal;Abdominal obesity and respiratory function in men and women in the EPIC-Norfolk Study, United Kingdom.Am J Epidemiol20041591140-114922. Jubber AS. Respiratory complications of obesity. Int J Clin Pract 2004;58:573–580.JubberASRespiratory complications of obesity.Int J Clin Pract200458573-580