Expired CME Article

Anemia Following Roux-en-Y Surgery for Morbid Obesity: A Review

Authors: Mark A. Marinella, MD, FACP, CNSP

Abstract

Morbid obesity is a significant problem in the Western world. Recently, there has been an increase in the number of patients undergoing surgical weight loss procedures. Currently, the most widely performed procedure is the Roux-en-Y gastric bypass operation which combines restriction of food intake with malabsorption of calories and various nutrients, resulting in weight loss and nutritional deficiencies, respectively. Various types of anemia may complicate Roux-en-Y and commonly include deficiencies of iron, folate, and vitamin B12. Iron deficiency is particularly common and may result from many mechanisms including poor intake, malabsorption, and mucosal bleeding from marginal ulceration. However, less appreciated etiologies of nutritional anemia include deficiencies of B-complex vitamins, ascorbic acid, and copper. Replacement of the missing or decreased constituent usually reverses the anemia. Since physicians of various medical and surgical specialties are often involved with the postoperative care of bariatric patients, a review of anemia in this patient population is warranted.


Key Points


* Anemia is common following bariatric surgery.


* Early causes of anemia include surgical blood loss and gastrointestinal bleeding.


* The most common causes of anemia occurring in the late postoperative period are iron, folate and vitamin B12 deficiencies.


* Copper deficiency should be considered in any Roux-en-Y patient with anemia, especially if no other cause is evident.

This content is limited to qualifying members.

Existing members, please login first

If you have an existing account please login now to access this article or view purchase options.

Purchase only this article ($25)

Create a free account, then purchase this article to download or access it online for 24 hours.

Purchase an SMJ online subscription ($75)

Create a free account, then purchase a subscription to get complete access to all articles for a full year.

Purchase a membership plan (fees vary)

Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

References

1. Brethauer SA, Chand B, Schauer PR. Risks and benefits of bariatric surgery: current evidence. Cleve Clin J Med 2006;73:993–1007.
 
2. Hedley AA, Ogden CL, Johnson CL, et al. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA 2004;291:2847–2850.
 
3. Shah M, Simha V, Garg A. Review: long-term impact of bariatric surgery on body weight, comorbidities, and nutritional status. J Clin Endocrinol Metab 2006;91:4223–4231.
 
4. Podnos YD, Jimenez JC, Wilson SE, et al. Complications after laparoscopic gastric bypass: a review of 3464 cases. Arch Surg 2003;138: 957–961.
 
5. Christou NV, Look D, Maclean LD. Weight gain after short- and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg 2006;244:734–740.
 
6. Brolin RE, LaMarca LB, Kenler HA, et al. Malabsorptive gastric bypass in patients with superobesity. J Gastrointest Surg 2002;6:195–205.
 
7. Nelson WK, Fatima J, Houghton SG, et al. The malabsorptive very, very long limb Roux-en-Y gastric bypass for super obesity: results in 257 patients. Surgery 2006;140:517–523.
 
8. Clements RH, Katasani VG, Palepu R, et al. Incidence of vitamin deficiency after laparoscopic Roux-en-Y gastric bypass in a university hospital setting. Am Surg 2006;72:1196–1204.
 
9. Mason ME, Jalagani H, Vinik AI. Metabolic complications of bariatric surgery: diagnosis and management issues. Gastroenterol Clin North Am 2005;34:25–33.
 
10. Parkes E. Nutritional management of patients after bariatric surgery. Am J Med Sci 2006;331:207–213.
 
11. Smith CD, Herkes SB, Behrns KE, et al. Gastric acid secretion and vitamin B12 absorption after vertical Roux-en-Y gastric bypass for morbid obesity. Ann Surg 1993;218:91–96.
 
12. Lublin M, McCoy M, Waldrep DJ. Perforating marginal ulcers after laparoscopic gastric bypass. Surg Endosc 2006;20:51–54.
 
13. Frezza EE, Herbert H, Ford R, et al. Endoscopic suture removal at gastrojejunal anastomosis after Roux-en-Y gastric bypass to prevent marginal ulceration. Surg Obes Relat Dis 2007;3:619–622.
 
14. Rasmussen JJ, Fuller W, Ali MR. Marginal ulceration after laparoscopic gastric bypass: an analysis of predisoposing factors in 260 patients. Surg Endosc 2007;21:1090–1094.
 
15. Sapala JA, Wood MH, Sapala MA, et al. Marginal ulcer after gastric bypass: a prospective 3-year study of 173 patients. Obes Surg 1998;8:505–516.
 
16. Tucker ON, Szomstein S, Rosenthal RJ. Nutritional consequences of weight-loss surgery. Med Clin North Am 2007;91:499–514, xii.
 
17. Simon SR, Zemel R, Betancourt S, et al. Hematologic complications of gastric bypass for morbid obesity. South Med J 1989;82:1108–1110.
 
18. Schlegel DM, Maglinte DD. The blind pouch syndrome. Surg Gynecol Obstet 1982;155:541–544.
 
19. Evers BM. Small intestine, in Townsend CM, Beauchamp RD, Evers BM, et al (eds): Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. Philadelphia, Elsevier Saunders, 2004, ed 17, pp 1323–1380.
 
20. Wylezol M, Gluck M, Zubik R, et al. Biliopancreatic diversion in Poland. J Physiol Pharmacol 2005;56(suppl 6):117–126.
 
21. Fabry H, Hendrickx L, Van Hee R. Blind loop syndrome after biliopancreatic diversion: a diagnostic challenge. Obes Surg 2001;11:643–645.
 
22. Vettoretto N, Poiatti R, Ghilardi G, et al. Blind pouch syndrome secondary to gastrojejunostomy. Report of a case. Chir Ital 2006;58: 263–266.
 
23. Hoffbrand AV, Moss PAH, Pettit JE. Megaloblastic anaemias and other macrocytic anemias, in Essential Haematology. Malden, MA, Blackwell Publishing, 2006, ed 5, pp 44–57.
 
24. Krajewski W, Kucharska M, Pilacik B, et al. Impaired vitamin B12 metabolic status in healthcare workers occupationally exposed to nitrous oxide. Br J Anaesth 2007;99:812–818.
 
25. Marie RM, Le Biez E, Busson P, et al. Nitrous oxide anesthesia-associated myelopathy. Arch Neurol 2000;57:380–382.
 
26. Babior BM. The megaloblastic anemias, in Beutler E, Coller BS, Lichtman MA, et al (eds): Williams Hematology. New York, McGraw-Hill, 2001, ed 6, pp 425–445.
 
27. Marinella MA. Refeeding syndrome and hypophosphatemia. J Intensive Care Med 2005;20:155–159.
 
28. Marinella MA. Refeeding syndrome, in Encyclopaedia of Molecular Mechanisms of Disease. Heidelberg, Germany, Springer-Verlag, in press.
 
29. Hoffbrand AV, Moss PAH, Pettit JE. Haemolytic anaemias, in Essential Haematology. Malden, MA, Blackwell Publishing, 2006, ed 5, pp 58–71.
 
30. Altuntas Y, Innice M, Basturk T, et al. Rhabdomyolysis and severe haemolytic anaemia, hepatic dysfunction and intestinal osteopathy due to hypophosphataemia in a patient after Billroth II gastrectomy. Eur J Gastroenterol Hepatol 2002;14:555–557.
 
31. Naqvi TA, Baumann MA, Chang JC. Post-operative thrombotic thrombocytopenic purpura: a review. Int J Clin Pract 2004;58:169–172.
 
32. Marinella MA. Refeeding syndrome, in Frequently Overlooked Diagnoses in Acute Care. Philadelphia, Hanley and Belfus, 2003, pp 79–83.
 
33. de Freitas Carvalho DA, Valezi AC, de Brito EM, et al. Rhabdomyolysis afer bariatric surgery. Obes Surg 2006;16:740–744.
 
34. Lagandre S, Arnalsteen L, Vallet B, et al. Predictive factors for rhabdomyolysis after bariatric surgery. Obes Surg 2006;16:1365–1370.
 
35. Faintuch J, de Cleva R, Pajecki D, et al. Rhabdomyolysis after gastric bypass: severity and outcome patterns. Obes Surg 2006;16:1209–1213.
 
36. Amaral JF, Thompson WR, Caldwell MD, et al. Prospective hematologic evaluation of gastric exclusion surgery for morbid obesity. Ann Surg 1985;201:186–193.
 
37. DeBiasse-Fortin MA. Minerals and trace elements, in Matarese LE, Gottschlich MM, (eds): Contemporary Nutrition Support Practice: A Clinical Guide. Philadelphia, Saunders, 2003, ed 2, pp 164–172.
 
38. Sayer JM, Long RG. A perspective on iron deficiency anemia. Gut 1993;34:1297–1299.
 
39. Holt JM, Gear MW, Warner GT. The role of chronic blood loss in the pathogenesis of postgastrectomy iron-deficiency anaemia. Gut 1970;11:847–850.
 
40. Mizon C, Ruz M, Csendes A, et al. Persistent anemia after Roux-en-Y gastric bypass. Nutrition 2007;23:277–280.
 
41. Marinella MA. “Tomatophagia” and iron-deficiency anemia. N Engl J Med 1999;341:60–61.
 
42. Wish JB. Assessing iron status: beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephrol 2006;1:S4–S8.
 
43. Avinoah E, Ovnat A, Charuzi I. Nutritional status seven years after Roux-en-Y gastric bypass surgery. Surgery 1992;111:137–142.
 
44. Toskes PP. Hematologic abnormalities following gastric resection. Major Probl Clin Surg 1976;20:119–128.
 
45. Brolin RE, Gorman RC, Milgrim LM, et al. Multivitamin prophylaxis in prevention of post-gastric bypass vitamin and mineral deficiencies. Int J Obes 1991;15:661–667.
 
46. Brolin RE, Gorman JH, Gorman RC, et al. Prophylactic iron supplementation after Roux-en-Y gastric bypass: a prospective, double-blind, randomized study. Arch Surg 1998;133:740–744.
 
47. Rhode BM, Shustik C, Christou NV, et al. Iron absorption and therapy after gastric bypass. Obes Surg 1999;9:17–21.
 
48. Munker R. Anemias: general considerations and microcytic, and megaloblastic anemias, in Munker R, Hiller E, Glass J, et al (eds): Modern Hematology: Biology and Clinical Management. Totowa, NJ, Humana Press, 2007, ed 2, pp 83–99.
 
49. Crowley LV, Olson RW. Megaloblastic anemia after gastric bypass for obesity. Am J Gastroenterol 1983;78:406–410.
 
50. Crowley LV. Chronic parietal cell dysfunction after reversal of gastric bypass. Am J Gastroenterol 1986;81:1188–1190.
 
51. Yale CE, Gohdes PN, Schilling RF. Cobalamin absorption and hematologic status after two types of gastric surgery for obesity. Am J Hematol 1993;42:63–66.
 
52. Rhode BM, Arseneau P, Cooper BA, et al. Vitamin B12 deficiency after gastric surgery for obesity. Am J Clin Nutr 1996;63:103–109.
 
53. Schilling RF, Gohdes PN, Hardie GH. Vitamin B12 deficiency after gastric bypass surgery for obesity. Ann Intern Med 1984;101:501–502.
 
54. Halverson JD, Zuckerman GR, Koehler RE, et al. Gastric bypass for morbid obesity: a medical-surgical assessment. Ann Surg 1981;194:152–160.
 
55. Crowley LV, Seay J, Mullin G. Late effects of gastric bypass for obesity. Am J Gastroenterol 1984;79:850–860.
 
56. Hvas AM, Nexo E. Diagnosis and treatment of vitamin B12 deficiency—An update. Haematologica 2006;91:1506–1512.
 
57. Shojania AM. Problems in the diagnosis and investigation of megaloblastic anemia. Can Med Assoc J 1980;122:999–1004.
 
58. Mahmoud MY, Lugon M, Anderson CC. Unexplained macrocytosis in elderly patients. Age Ageing 1996;25:310–312.
 
59. Alvarez-Leite JI. Nutrient deficiencies secondary to bariatric Surgery. Curr Opin Clin Nutr Metab Care 2004;7:569–575.
 
60. Drummond JF, White DK, Damm DD. Megaloblastic anemia with oral lesions: a consequence of gastric bypass surgery. Oral Surg Oral Med Oral Pathol 1985;59:149–153.
 
61. Martin L, Chavez GF, Adams MJ Jr, et al. Gastric bypass surgery as maternal risk factor for neural tube defects. Lancet 1988;1:640–641.
 
62. Knudsen LB, Kallen B. Gastric bypass, pregnancy, and neural tube defects. Lancet 1986;2:227.
 
63. Brolin RE, Gorman JH, Gorman RC, et al. Are vitamin B12 and folate deficiency clinically important after Roux-en-Y gastric bypass? J Gastrointest Surg 1998;2:436–442.
 
64. Elliot K. Nutritional considerations after bariatric surgery. Crit Care Nurs Q 2003;26:133–138.
 
65. Boosalis MG. Vitamins, in Matarese LE, Gottschlich MM (eds): Contemporary Nutrition Support Practice: A Clinical Guide. Philadelphia, Saunders, 2003, pp 145–163.
 
66. Anonymous. Vitamins of the B complex. Br Med J 1968;4(5632):690–691.
 
67. Marinella MA. Wernicke’s encephalopathy, in Recognizing Clinical Patterns: Clues to a Timely Diagnosis. Philadelphia, Hanley and Belfus, 2002, p 102.
 
68. Bazarbachi A, Muakkit S, Ayas M, et al. Thiamine-responsive myelodysplasia. Br J Haematol 1998;102:1098–1100.
 
69. Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr 2003;77:1352–1360.
 
70. Foy H, Kondi A. A case of true redcell aplastic anaemia successfully treated with riboflavin. J Pathol Bacteriol 1953;65:559–564.
 
71. Lane M, Alfrey CP Jr. The anemia of human riboflavin deficiency. Blood 1965;25:432–442.
 
72. Kertesz SG. Pellagra in 2 homeless men. Mayo Clin Proc 2001;76:315–318.
 
73. Spivak JL, Jackson DL. Pellagra: an analysis of 18 patients and a review of the literature. Johns Hopkins Med J 1977;140:295–309.
 
74. Beutler E. Anemia due to other nutritional deficiencies, in Beutler E, Coller BS, Lichtman MA, et al (eds): Williams Hematology. New York, McGraw-Hill, 2002, ed 6, pp 471–475.
 
75. Ronnenberg AG, Goldman MB, Aitken IW, et al. Anemia and deficiencies of folate and vitamin B6 are common and vary with season in Chinese women of childbearing age. J Nutr 2000;130:2703–2710.
 
76. Clayton PT. B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis 2006;29:317–326.
 
77. Cohen SA, Paeglow RJ. Scurvy: an unusual cause of anemia. J Am Board Fam Pract 2001;14:314–316.
 
78. Ho V, Prinsloo P, Ombiga J. Persistent anaemia due to scurvy. N Z Med J 2007;120:U2729.
 
79. Cox EV, Meynell MJ, Northam BE, et al. The anaemia of scurvy. Am J Med 1967;42:220–227.
 
80. Todd LM, Godber IM, Gunn IR. Iatrogenic copper deficiency causing anaemia and neutropenia. Ann Clin Biochem 2004;41:414–416.
 
81. Vulpe CD, Kuo YM, Murphy TL, et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 1999;21:195–199.
 
82. Nagano T, Toyoda T, Tanabe H, et al. Clinical features of hematological disorders caused by copper deficiency during long-term enteral nutrition. Intern Med 2005;44:554–559.
 
83. Gregg XT, Reddy V, Prchal JT. Copper deficiency masquerading as myelodysplastic syndrome. Blood 2002;100:1493–1495.
 
84. Kumar N, Ahlskog JE, Gross JB Jr. Acquired hypocupremia after gastric surgery. Clin Gastroenterol Hepatol 2004;2:1074–1079.
 
85. Chen CC, Takeshima F, Miyazaki T, et al. Clinicopathological analysis of hematological disorders in tube-fed patients with copper deficiency. Intern Med 2007;46:839–844.
 
86. Hoffman HN II, Phyliky RL, Fleming CR. Zinc-induced copper deficiency. Gastroenterology 1988;94:508–512.
 
87. Mason EE. Starvation injury after gastric reduction for obesity. World J Surg 1998;22:1002–1007.
 
88. Caro J, Silver R, Erslev AJ, et al. Erythropoietin production in fasted rats. Effects of thyroid hormones and glucose supplementation. J Lab Clin Med 1981;98:860–868.
 
89. Delmonte L, Aschkenasy A, Eyquem A. Studies on the hemolytic nature of protein-deficiency anemia in the rat. Blood 1964;24:49–68.
 
90. Borelli P, Blatt S, Pereira J, et al. Reduction of erythroid progenitors in protein-energy malnutrition. Br J Nutr 2007;97:307–314.
 
91. Melvin JD, Watts RG. Severe hypophosphatemia: a rare cause of intravascular hemolysis. Am J Hematol 2002;69:223–224.
 
92. Marinella MA. The refeeding syndrome and hypophosphatemia. Nutr Rev 2003;61:320–323.