Letter to the Editor

Apolipoprotein ε4 Homozygosity and Essential Hypertension

Authors: Genovefa D. Kolovou, MD, PhD, Katherine K. Anagnostopoulou, MSc, Dennis V. Cokkinos, MD

Abstract

A 67-year-old Greek woman with a body mass index of 25 kg/m2 was referred to the Lipid Clinic for dyslipidemia. She had stopped smoking 20 years previously, had been treated for hypertension for the past 10 years, and suffered a myocardial infarction 3 years prior. Her family history included stroke in her father at the age of 65, and hypertension in her son at age 47.

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References

1. Hopkins PN. Familial hypercholesterolemia-Improving treatment and meeting guidelines. Int J Cardiol2003;89:13–23.
 
2. Kolovou G, Yiannakouris N, Hatzivassiliou M, et al. Association of apolipoprotein E polymorphism with myocardial infarction in Greek patients with coronary artery disease. Curr Med Res Opin2002;18:118–124.
 
3. van Bockxmeer FM, Mamotte CD. Apolipoprotein epsilon 4 homozygosity in young men with coronary heart disease. Lancet 1992;340:879–880.
 
4. Tiret L, de Knijff P, Menzel HJ, et al. Apo E polymorphism and predisposition to coronary heart disease in youths of different European populations. The EARS study. European Atherosclerosis Research Study. Arterioscler Thromb 1994;14:1617–1624.
 
5. Yilmaz H, Isbir T, Agachan B, et al. Is epsilon4 allele of apolipoprotein E associated with more severe end-organ damage in essential hypertension? Cell Biochem Funct 2001;19:191–195.