Letter to the Editor

Brugada Syndrome, Epilepsy and Pemphigus Vulgaris

Authors: Marzia Caproni, MD, Daniele Torchia, MD, Leonardo Parigi, MD, Paolo Fabbri, MD


To the Editor:

A 67-year-old man was affected for 18 years by pemphigus vulgaris; he was maintained on oral methylprednisolone 8 mg daily. He was also taking enalapril, potassium canrenoate and butizide for arterial hypertension. Prophylactic therapy with phenytoin 100 mg and lamotrigin 100 mg daily had been established several years before because of generalized idiopathic epilepsy.

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1.Antzelevitch C, Brugada P, Borggrefe M, et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005;111:659–670.
2.Fauchier L, Babuty D, Cosnay P. Epilepsy, Brugada syndrome and the risk of sudden unexpected death. J Neurol 2000;247:643–644.
3.Dourmishev AL, Rahman MA. Phenobarbital-induced pemphigus vulgaris. Dermatologica 1986;173:256–258.
4.Sehgal VN, Srivastava G. Corticosteroid-unresponsive pemphigus vulgaris following antiepileptic therapy. Int J Dermatol 1988;27:258.
5.Patterson CR, Davies MG. Carbamazepine-induced pemphigus. Clin Exp Dermatol 2003;28:98–99.