Case Report

Childhood Hepatitis A Virus Infection Complicated by Pseudotumor Cerebri

Authors: Rajoo Thapa MD, Apurba Ghosh MD, MRCP (Ire), MRCP (UK), FRCPCH, Swapan Mukherjee MD, DM

Abstract

Abstract:A 4-year-old male child with hepatitis A virus (HAV) infection is presented. His disease course was complicated by the development of pseudotumor cerebri (PC), as evidenced by symptoms and signs of increased intracranial pressure in the presence of normal cerebrospinal fluid examination and cranial magnetic resonance scan. The neurological examination was normal with the exception of the right-sided sixth cranial nerve paresis. His neurological course was uncomplicated with spontaneous recovery within three days. To our knowledge, this is the first report in the English literature of PC complicating the course of HAV in a child.

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References

References1. Haslam RHA. Pseudotumor cerebri, in Behrman RE, Kliegman RM, Jenson HD, et al (eds): Nelson Textbook of Pediatrics. Philadelphia, Saunders Elsevier, 2007, ed 18, pp 2525–2526.2. Viral hepatitis, in Park K (ed): Park's Textbook of Preventive and Social Medicine. Jabalpur, Banarsidas Bhanot, 2007, ed 19, pp 167–175.3. Leneman F. The Guillain-Barre syndrome. Definition, etiology, and review of 1,100 cases. Arch Intern Med 1966;118:139–144.LenemanFThe Guillain-Barre syndrome. Definition, etiology, and review of 1,100 cases.Arch Intern Med1966118139-1444. Tabor E. Guillain-Barre syndrome and other neurologic syndromes in hepatitis A, B, and non-A, non-B. J Med Virol 1987;21:207–216.TaborEGuillain-Barre syndrome and other neurologic syndromes in hepatitis A, B, and non-A, non-B.J Med Virol198721207-2165. Azuri J, Lerman-Sagie T, Mizrahi A, et al. Guillain-Barre syndrome following serological evidence of hepatitis A in a child. Eur J Pediatr 1999;158:341–342.AzuriJ]]Lerman-SagieT]]MizrahiA&etal;Guillain-Barre syndrome following serological evidence of hepatitis A in a child.Eur J Pediatr1999158341-3426. Kocabas E, Yildisdaz D. A child with Guillain-Barré syndrome caused by acute hepatitis A infection. Indian Pediatr 2004;41:92–93.KocabasE]]YildisdazDA child with Guillain-Barré syndrome caused by acute hepatitis A infection.Indian Pediatr20044192-937. Johnston CL, Schwartz M, Wansbrough-Jones MH. Acute inflammatory polyradiculoneuropathy following type A viral hepatitis. Postgrad Med J 1981;57:647–648.JohnstonCL]]SchwartzM]]Wansbrough-JonesMHAcute inflammatory polyradiculoneuropathy following type A viral hepatitis.Postgrad Med J198157647-6488. Grover B, Dalessandro L, Sanders JG, et al. Severe viral hepatitis A infection, Landry-Guillain-Barre syndrome, and hereditary elliptocytosis. South Med J 1986;79:251–252.GroverB]]DalessandroL]]SandersJG&etal;Severe viral hepatitis A infection, Landry-Guillain-Barre syndrome, and hereditary elliptocytosis.South Med J198679251-2529. Mihori A, Nakayama M, Ono S, et al. [Ataxic form of Guillain-Barré syndrome associated with acute hepatitis A-a case report]. Rinsho Shinkeigaku 1998;38:242–245 (in Japanese).10. Breningstall GN, Belani KK. Acute transverse myelitis and brainstem encephalitis associated with hepatitis A infection. Pediatr Neurol 1995;12:169–171.BreningstallGN]]BelaniKKAcute transverse myelitis and brainstem encephalitis associated with hepatitis A infection.Pediatr Neurol199512169-17111. Khemiri M, Ouederni M, Barsaoui S. A new case of acute transverse myelitis following hepatitis A virus infection. Med Mal Infect 2007;37:237–239.KhemiriM]]OuederniM]]BarsaouiSA new case of acute transverse myelitis following hepatitis A virus infection.Med Mal Infect200737237-23912. Cam S, Ertem D, Koroglu OA, et al. Hepatitis A virus infection presenting with seizures. Pediatr Infect Dis J 2005;24:652–653.CamS]]ErtemD]]KorogluOA&etal;Hepatitis A virus infection presenting with seizures.Pediatr Infect Dis J200524652-65313. Pelletier B, Elghozi D, Trepo C, et al. Mononeuritis in acute viral hepatitis. Digestion 1985;32:53–56.PelletierB]]ElghoziD]]TrepoC&etal;Mononeuritis in acute viral hepatitis.Digestion19853253-5614. Varona L, Sagasta A, Martin-Gonzálvez JA, et al. Cranial neuropathies and liver failure due to hepatitis A. Neurology 1996;46:1774–1775.VaronaL]]SagastaA]]Martin-GonzálvezJA&etal;Cranial neuropathies and liver failure due to hepatitis A.Neurology1996461774-177515. Islam S, McDonald JA. Sensory neuropathy in the prodromal phase of hepatitis A and review of the literature. J Gastroenterol Hepatol 2000;15:809–811.IslamS]]McDonaldJASensory neuropathy in the prodromal phase of hepatitis A and review of the literature.J Gastroenterol Hepatol200015809-81116. Tuthill D, Verrier Jones ER. Acute cerebellar ataxia after subclinical hepatitis A infection. Pediatr Infect Dis J 1996;15:546–547.TuthillD]]Verrier JonesERAcute cerebellar ataxia after subclinical hepatitis A infection.Pediatr Infect Dis J199615546-547