Primary Article
Cicatricial Pemphigoid A study of 15 cases
Abstract
AbstractCicatricial pemphigoid (benign mucusal pemphigoid) is a chronic, nonhereditary blistering disease which affects predominantly the mucous membranes, particularly the eyes and mouth, and may lead to scarring. The skin is involved in about one third of cases. Histopathathologically, the blister is subepidermal. Immunofluoresent studies have shown that the majority of persons with cicatricial pemphigold have deposition of immunoglobulin at the basement membrane zone of the affected skin, oral mucosa, and conjunctiva. Occasionally the serum may also contain circulating basement membrane zone antibedies. Histopathologic and immunofluorescent studies may be of help in differentiating cicatricial pemphigold from diseases with which it may be confused Clinically. A relationship between cicatricial pemphigold and bullous pemphigold seems likely, and there is evidence to suggest that both diseases may be autoimmune in nature.This content is limited to qualifying members.
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