The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists.

SMJ // Article

Case Report

Coexistence of Systemic Lupus Erythematosus and Myasthenia Gravis

Authors: PAUL J. KILLIAN, MD, GARY S. HOFFMAN, MD

Abstract

THERE HAVE BEEN 19 case reports of the coexistence of myasthenia gravis (MG) and systemic lupus erythematosus (SLE).1–17 SLE and MG are considered autoimmune diseases and as such may have clinical and serologic overlap.12 A critical analysis of the literature reveals that in many of these case reports the diagnosis of SLE is indefinite. Combined data from major studies, however, reveal a definite increase in incidence of these two conditions occurring in the same patient. This paper describes a patient with well documented SLE and MG and reviews the literature concerning the association between these diseases.

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