Invited Commentary

Commentary on “Deep Brain Stimulation for Treatment-Refractory Depression”

Authors: Kathleen Mary Patchan, MD


Major depressive disorder is a chronic, disabling, and potentially life-threatening disorder that has a lifetime prevalence of 15% to 20%. A 2015 article published in Lancet evaluating the global burden of disease ranked major depressive disorder as the second leading cause of disability in 2013, contributing to 51,784 disability-years.1 Although various treatment modalities, including antidepressants, adjunctive medications, psychotherapy, and electroconvulsive therapy have been developed, many individuals continue to experience clinical symptoms and few experience complete remission.

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1. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015;386:743-800.
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