Primary Article

Diazepam Infusion in Tetanus Correlation of Drug Levels With Effect

Authors: JOSEPH F. DASTA MSc, KENNETH L. BRIER BSc, MA, GREGORY A. KIDWELL MD, STEVEN A. SCHONFELD MD, DANIEL COURI PhD

Abstract

A patient with muscle spasms and rigidity associated with tetanus was successfully treated with a continuous infusion of diazepam. This beneficial response was associated with a minimal serum diazepam concentration of 500 ng/ml. The major metabolite of diazepam, DMD, did not appear to exert substantial activity. Guidelines for dosing diazepam are provided.

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