The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists.

SMJ // Article

Primary Article

Efficacy of Histamine H1 and H2 Receptor Blockers in the Anesthetic Management During Operation for Hydatid Cysts of Liver and Lungs

Authors: J REDDY KAMBAM MD, RICHARD DYMOND MD, MICHAEL KRESTOW MD, ROBERT E. HANDTE MD

Abstract

ABSTRACT: We studied the effects of preoperative administration of histamine (H1 and H2) receptor blockers on hemodynamic changes in two groups of patients having operation for hydatid cyst. Patients in group 1 received no antihistaminics, whereas those in group 2 were pretreated with both H1 (diphenhydramine) and H2 (cimetidine) receptor blockers. Even though there were significant hemodynamic responses associated with spillage of hydatid cyst contents in both groups, the hemodynamic changes were significantly less in the patients who had received histamine receptor blockers. We conclude that the preoperative administration of H1 and H2 receptor blockers to patients having hydatid cyst surgery is beneficial.

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