Editorial

GALOP Syndrome: A Treatable Immune-mediated Late-age Onset Polyneuropathy With Gait Ataxia

Authors: Alireza Minagar, MD

Abstract

Various studies have established an association between elevated titers of antibodies against sulfatide (the main acidic glycosphingolipid component of the myelin sheath) and a number of systemic and neurologic disorders. These auto-antibodies have been reported in patients with idiopathic thrombocytopenic purpura, 1 autoimmune chronic active hepatitis, 2 human immunodeficiency virus, 3 Guillain-Barré syndrome, 4 and chronic inflammatory demyelinating polyradiculoneuropathy. 5

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References

1. Van Villet HH, Kappers-Klune MC, van der Hel JW, Abels J. Antibodies against glycosphingolipids in sera of patients with idiopathic thrombocytopenic purpura. Br J Haematol 1987; 67: 103–108.
 
2. Toda G, Ikeda Y, Kashiwagi M, Iwamori M, Oka H. Hepatocyte plasma membrane glycosphingolipid reactive with sera from patients with autoimmune chronic active hepatitis; its identification as sulfatide. Hepatology 1990; 12: 664–670.
 
3. Petratos S, Turnbull VJ, Papadopoulos R, Ayers M, Gonzales MF. High titer anti-sulfatide antibodies in HIV-infected individuals. NeuroReport 1999; 10: 2557–2562.
 
4. Van den Berg LH, Lankamp CL, de Jager AE, et al. Anti-sulphatide antibodies in peripheral neuropathy. J Neurol Neurosurg Psychiatry 1993; 56: 1164–1168.
 
5. Pestronk A, Li F, Griffin J, et al. Polyneuropathy syndromes associated with serum antibodies to sulfatide and myelin-associated glycoprotein. Neurology 1991; 41: 357–362.
 
6. Latov N. Pathogenesis and therapy of neuropathies associated with monoclonal gammopathies. Ann Neurol 1995; 37: S32–S42.
 
7. Pestronk A, Choksi R, Bieser K, et al. GALOP syndrome: a treatable autoimmune gait disorder with late-age onset. Ann Neurol 1993; 34: 268–269.
 
8. Pestronk A, Choksi R, Bieser K, et al. Treatable gait disorder and polyneuropathy associated with high titer serum IgM binding to antigens that copurify with myelin-associated glycoprotein. Muscle Nerve 1994; 17: 1293–1300.
 
9. Alpert JN. GALOP syndrome: case report with a 7-year follow-up. South Med J 2004; 97; 410–412.