Case Report
GALOP Syndrome: Case Report with 7-year Follow-up
Abstract
An elderly woman complaining of a gait disorder was found to have the GALOP syndrome (gait ataxia, late-onset polyneuropathy). She exhibited mild distal weakness and sensory loss in the legs, a positive Romberg, and an unsteady gait. Serum immunofixation disclosed a monoclonal IgM-κ protein. There was specific IgM binding to galopin, a central nervous system white matter antigen. Periodic treatment with intravenous immunoglobulin has alleviated her neurologic symptoms. She has now been followed for 7 years and maintained significant improvement in neurologic symptoms and signs.This content is limited to qualifying members.
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References
1. Pestronk A, Choksi R, Bieser K, et al. Treatable gait disorders and polyneuropathy associated with high titer serum IgM binding to antigens that copurify with myelin associated glycoprotein. Muscle and Nerve, 1994; 17: 1293–1300.
2. Pestronk A, Choksi R, Bieser K, et al. GALOP syndrome: a treatable autoimmune gait disorder with late-age onset. Ann Neurol 1993; 34: 268–269.
3. Pestronk A.R Chronic immune polyneuropathies and serum autoantibodies, in Rolak LA and Harati Y: Neuroimmunology for the clinician. Boston, Butterworth-Heinemann, 1997, pp 237–251.
4. Dalakas MC. Mechanism of action of intravenous immunoglobulin and therapeutic considerations in the treatment of autoimmune neurologic diseases. Neurology 1998; 51( 6 suppl 5): S2–S8.
