Gastric Sarcoidosis: A Case Report and Review of the Literature
Sarcoidosis is a systemic granulomatous disease of unknown etiology that is characterized by the formation of noncaseating granulomas. Gastrointestinal (GI) tract involvement in sarcoidosis is rare. Gastric sarcoidosis, particularly involving the antrum, affects approximately 10% of patients with systemic disease.1 GI sarcoidosis commonly occurs subclinically, with clinical manifestations present in only 0.1 to 0.9% of patients with the disease.
This is a rare case report of an individual with symptomatic gastric sarcoidosis. The patient presented with weight loss, nausea, and early satiety. An EGD and colonoscopy were performed and were grossly normal. However, biopsies of the gastric antrum revealed noncaseating granulomatous inflammation involving the gastric mucosa. Corticosteroid therapy was started and the symptoms abated almost immediately. We also offer a review of the literature.
* Symptomatic gastric sarcoidosis is a rare disease.
* The clinical manifestations of gastric sarcoidosis include abdominal pain, weight loss, nausea, vomiting, early satiety, and upper GI bleeding.
* Histological evidence of noncaseating granulomas consistent with sarcoidosis is necessary for diagnosis.
* Treatment with corticosteroid therapy usually causes resolution of symptoms.
This content is limited to qualifying members.
If you have an existing account please login now to access this article or view your purchase options.
Create a free account, then purchase this article to download or access it online for 24 hours.
Create a free account, then purchase a subscription to get complete access to all articles for a full year.