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SMJ // Article

Original Article

Gender-Based Differences in Mental Health Outcomes Following Breast Surgery: Insights from Epic Cosmos

Authors: Shelley R. Edwards, BS, Ashlie A. Elver, MD, Keely B. Frederick, BS, MHA, Savanah Walker, MD, Seth J. Kalin, MD, Laura S. Humphries, MD, Marc Walker, MD, MBA, Ian C. Hoppe, MD

Abstract

Objectives: Individuals with conditions affecting the appearance of the breast may suffer from psychosocial distress contributing to mental health disease. Breast surgery is one solution offered to mitigate these effects. Psychosocial distress of breast appearance may be experienced differently among genders. This study investigates the interplay of breast surgery, mental health conditions, and gender.

Methods: Retrospective data from 2010 to 2020 were queried from Cosmos, a national deidentified database from the Epic electronic health record, for patients diagnosed as having the nononcologic breast conditions gynecomastia, breast hypertrophy or macromastia, and asymmetry. Patients were divided into male and female cohorts. Primary outcomes compared the rates of anxiety, depression, and suicidality in those who did or did not receive breast surgery.

Results: There were 232,138 patients with breast diagnoses, 30,521 (13.15%) of whom underwent breast surgery. Mental health diagnoses were significantly lower for female surgical patients compared with female nonsurgical patients. Males, however, demonstrated an opposite trend, in which surgical patients experienced higher rates of anxiety (24.3% vs 19.9%; P < 0.001), depression (22.4% vs 19.7%; P = 0.003), and self-harm (2.7% vs 1.6%; P < 0.001).

Conclusions: Breast surgery is experienced differently among genders as demonstrated by the mental health outcomes in this study. A concerning trend was identified in which males who underwent surgery were more likely to suffer from mental health conditions, most notably in the preoperative period. Enhanced gender-specific counseling may help address the heightened risk of mental health conditions, particularly in males, identified in this study.

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References

1. Rew L, Young C, Harrison T, et al. A systematic review of literature on psychosocial aspects of gynecomastia in adolescents and young men. J Adolesc 2015;43:206–212.
 
2. Nuzzi LC, Firriolo JM, Pike CM, et al. The effect of surgical treatment on the quality of life of young women with breast asymmetry: a longitudinal, cohort study. Plast Reconstr Surg 2020; 146:400e–408e.
 
3. Ordaz DL, Thompson JK. Gynecomastia and psychological functioning: a review of the literature. Body Image 2015;15:141–148.
 
4. Nuzzi LC, Cerrato FE, Webb ML, et al. Psychological impact of breast asymmetry on adolescents: a prospective cohort study. Plast Reconstr Surg 2014;134:1116–1123.
 
5. Dikmen S, Dissiz M. Does large breast problem and macromastia surgery affect a woman's body image, depression level, sexual life, and quality of life? A prospective study. Rev Assoc Med Bras (1992) 2021;67:1659–1664.
 
6. International Society of Aesthetic Plastic Surgery. ISAPS international survey on aesthetic/cosmetic procedures performed in 2022. https://www.isaps.org/media/a0qfm4h3/isaps-global-survey_2022.pdf. Accessed November 27, 2023.
 
7. Vieira RADC, Bailão-Junior A1, De Oliveira-Junior I. Does breast oncoplastic surgery improve quality of life? Front Oncol 2023;12:1099125.
 
8. Char S, Bloom JA, Erlichman Z, et al. A comprehensive literature review of patient-reported outcome measures (PROMs) among common breast reconstruction options: what types of breast reconstruction score well? Breast J 2021;27:322–329. doi:10.1111/tbj.14186.
 
9. Fanakidou I, Zyga S, Alikari V, et al. Mental health, loneliness, and illness perception outcomes in quality of life among young breast cancer patients after mastectomy: the role of breast reconstruction. Qual Life Res 2018;27:539–543.
 
10. Wojtkowska A, Zaborski D, Modrzejewski A, et al. The effect of cosmetic surgery on mental self-image and life satisfaction in women undergoing breast augmentation: an intermediate role of evaluating the surgery as one of the most important life events. J Plast Reconstr Aesthet Surg 2022;75:1842–1848.
 
11. Mello AA, Domingos NAM, Miyazaki MC. Improvement in quality of life and self-esteem after breast reduction surgery. Aesthetic Plast Surg 2010;34:59–64.
 
12. Iwuagwu OC, Walker LG, Stanley PW, et al. Randomized clinical trial examining psychosocial and quality of life benefits of bilateral breast reduction surgery. Br J Surg 2006; 93:291–294.
 
13. Lonie S, Sachs R, Shen A, et al. A systematic review of patient reported outcome measures for women with macromastia who have undergone breast reduction surgery. Gland Surg 2019;8: 431–440.
 
14. Mousavi Z, Abolhasanpour N, Naseri A, et al. Cosmetic breast implants and the risk of suicide: a systematic review and meta-analysis. Iran J Psychiatry 2023;18:319–331.
 
15. Baxter NB, Howard JC, Chung KC. A systematic review of health disparities research in plastic surgery. Plast Reconstr Surg 2021;147:529–537.
 
16. Kowalski C, Steffen P, Ernstmann N, et al. Health-related quality of life in male breast cancer patients. Breast Cancer Res Treat 2012;133:753–757.
 
17. Motmans J, Meier P, Ponnet K, et al. Female and male transgender quality of life: socioeconomic and medical differences. J Sex Med 2012;9:743–750.
 
18. Lowenstein NA, Ostergaard PJ, Haber DB, et al. Sex differences in outcomes after arthroscopic bankart repair. BMJ Open Sport Exerc Med 2020;6:e000965.
 
19. O'Hara MW, Ghoneim MM, Hinrichs JV, et al. Psychological consequences of surgery. Psychosom Med 1989;51:356–370.
 
20. Chen W, Lv X, Xu X, et al. Meta-analysis for psychological impact of breast reconstruction in patients with breast cancer. Breast Cancer 2018;25:464–469.
 
21. Padmalatha S, Tsai YT, Ku HC, et al. Higher risk of depression after total mastectomy versus breast reconstruction among adult women with breast cancer: a systematic review and metaregression. Clin Breast Cancer 2021;21:e526–e538.
 
22. Tucker RP, Testa RJ, Simpson TL, et al. Hormone therapy, gender affirmation surgery, and their association with recent suicidal ideation and depression symptoms in transgender veterans. Psychol Med 2018;48:2329–2336.
 
23. White AG, Nuzzi LC, McNamara CT, et al. Mental health conditions and health-related quality of life changes after reduction mammaplasty in younger patients. Plast Reconstr Surg Glob Open 2023;11:e4902.
 
24. Pérez-Panzano E, Gascón-Catalán A, Sousa-Domínguez R, et al. Reduction mammaplasty improves levels of anxiety, depression and body image satisfaction in patients with symptomatic macromastia in the short and long term. J Psychosom Obstet Gynaecol 2017;38: 268–275.
 
25. Kasielska-Trojan A, Antoszewski B. Gynecomastia surgery—impact on life quality: a prospective case-control study. Ann Plast Surg 2017;78:264–268.
 
26. McNamara CT, Nuzzi LC, Firriolo JM, et al. Complications and quality of life following gynecomastia correction in adolescents and young men. Plast Reconstr Surg 2022;149:1062e–1070e.
 
27. Nuzzi LC, Firriolo JM, Pike CM, et al. The effect of surgical treatment for gynecomastia on quality of life in adolescents. J Adolesc Health 2018;63:759–765.
 
28. Davanço RA, Sabino Neto M, Garcia EB, et al. Quality of life in the surgical treatment of gynecomastia. Aesthetic Plast Surg 2009;33:514–517.
 
29. Lashin R, Youssef RA, Elshahat A, et al. Postoperative psychological impact on teenagers after gynecomastia correction. Plast Reconstr Surg Glob Open 2023;11:e5094.
 
30. Donovan T, Flynn M. What makes a man a man? The lived experience of male breast cancer. Cancer Nurs 2007;30:464–470.
 
31. Ridha H, Colville RJ, Vesely MJ. How happy are patients with their gynaecomastia reduction surgery? J Plast Reconstr Aesthet Surg 2009;62:1473–1478.
 
32. Younas A, Sundus A, Inayat S. Transitional experience of men with breast cancer from diagnosis to survivorship: an integrative review. Eur J Oncol Nurs 2019;42:141–152.
 
33. Thompson EH, Haydock AS. Men’s lived experiences with breast cancer: the double consciousness of marginal men. Sex Roles 2020;82:28–43.
 
34. Browne JA, Sandberg BF, D'Apuzzo MR, et al. Depression is associated with early postoperative outcomes following total joint arthroplasty: a nationwide database study. J Arthroplasty 2014;29:481–483.
 
35. Wong SE, Colley AK, Pitcher AA, et al. Mental health, preoperative disability, and postoperative outcomes in patients undergoing shoulder arthroplasty. J Shoulder Elbow Surg 2018;27:1580–1587.
 
36. Fisher DA, Dierckman B, Watts MR, et al. Looks good but feels bad: factors that contribute to poor results after total knee arthroplasty. J Arthroplasty 2007;22(6 Suppl 2):39–42.
 
37. Vissers MM, Bussmann JB, Verhaar JA, et al. Psychological factors affecting the outcome of total hip and knee arthroplasty: a systematic review. Semin Arthritis Rheum 2012;41:576–588.
 
38. Vranceanu AM, Jupiter JB, Mudgal CS, et al. Predictors of pain intensity and disability after minor hand surgery. J Hand Surg Am 2010;35:956–960.