Letter to the Editor

Hypersensitivity to Furosemide

Authors: Catherine I. Dalton, MD, Marilyn S. Pacheco, MD


To the Editor:

“Drug eruptions are probably the most frequent of all manifestations of drug sensitivity.”1 They range from mild, short-lived maculopapular rashes that subside, despite continuation of the medication, to severe forms such as Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN). In fact, “cutaneous drug eruptions occur in 2–3% of all hospitalized patients.”2

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1. Breathnach SM. Adverse cutaneous reactions to drugs. Clin Med 2002;2:15–19.
2. Brönnimann M, Yawalkar N. Histopathology of drug-induced exanthems: is there a role in diagnosis of drug allergy? Curr Opin Allergy Clin Immunol 2005;5:317–321.
3. Noce R, Paredes BE, Pichler WJ, et al. Acute generalized exanthematic pustulosis (AGEP) in a patient treated with furosemide. Am J Med Sci 2000;320:331–333.
4. Kitamura K, Aihara M, Osawa J, et al. Sulfhydryl drug-induced eruption: a clinical and histological study. J Dermatol 1990;17:44–51.
5. Bourgain C, Bienvenu T, Cremieux AC, et al. Bumetanide as replacement therapy in furosemide-induced vasculitis. Presse Méd 1990;19:1504–1505 (in French).
6. Gratadour P, Guillaume C, Bui-Xuan B, et al. Absence of cross-allergy between furosemide and bumetanide. Presse Méd 1990;19:1504 (in French).