The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists.

SMJ // Article

Primary Article

Infectious Mononucleosis With Severe Neutropenia and Opsonic Antineutrophil Activity

Authors: MAJ DENNIS L. STEVENS, E. DALE EVERETT MD, LAURENCE A. BOXER MD, MAJ RONALD A. LANDEFELD MC

Abstract

Severe granulocytopenia is an uncommon complication of infectious mononucleosis, only 18 cases having been reported previously. Our review and experience with this case would indicate that (1) severe granulocytopenia is usually diagnosed at about the third or fourth week of illness, (2) bone marrow examination most commonly reveals lack of mature neutrophil precursors in the myelocytic series, (3) the duration is usually short, lasting about a week, and (4) most patients recover without treatment. The laboratory findings in our case suggest that the neutropenia may be antibody mediated.

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