Abstract
Abstract:Mantle cell lymphoma is a well-characterized category of mature B-cell lymphoma with aberrant coexpression of CD5 antigen. This subtype of lymphoma is genetically defined by t(11;14) resulting in upregulation of cyclin D1 protein. In clinical practice, mantle cell lymphoma is typically diagnosed based on combination of morphology, CD20/CD5 coexpression, and nuclear staining of cyclin D1 protein by immunohistochemistry. Although other neoplastic processes can also be cyclin D1 positive, documentation of cyclin D1 positivity in a CD5-positive B-cell process is virtually diagnostic of mantle cell lymphoma. However, on morphologic grounds, it is well known that mantle cell lymphoma can mimic other subtypes of B-cell lymphoid neoplasm. We identified several unusual examples of immunohistochemically confirmed cyclin D1-positive mantle cell lymphoma with morphologic features overlapping with a wide variety of other subtypes of mature B-cell lymphomas including follicular, marginal zone, small lymphocytic and Burkitt lymphoma.
This content is limited to qualifying members.
If you have an existing account please login now to access this article or view purchase options.
Create a free account, then purchase this article to download or access it online for 24 hours.
Create a free account, then purchase a subscription to get complete access to all articles for a full year.
References
References1. Non-Hodgkin’ Lymphoma Classification Project. National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas: summary and description of a Working Formulation for clinical usage. Cancer 1982;49:2112–2135.&NA;Non-Hodgkin’ Lymphoma Classification Project. National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas: summary and description of a Working Formulation for clinical usage.Cancer1982492112-21352. Lardelli P, Bookman MA, Sundeen J, et al. Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunophenotypic spectrum and clinical correlations. Am J Surg Pathol 1990;14:752–763.LardelliP]]BookmanMA]]SundeenJ&etal;Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunophenotypic spectrum and clinical correlations.Am J Surg Pathol199014752-7633. Weisenburger DD, Nathwani BN, Diamond LW, et al. Malignant lymphoma, intermediate lymphocytic type. A clinicopathologic study of 42 cases. Cancer 1981;48:1415–1425.WeisenburgerDD]]NathwaniBN]]DiamondLW&etal;Malignant lymphoma, intermediate lymphocytic type. A clinicopathologic study of 42 cases.Cancer1981481415-14254. Jaffe ES, Harris NL, Stein H, et al (eds). World Health Organization Classification of Tumours. Tumours of the Haematopoietic and Lymphoid Tissues. Lyon, France, IARC Press, 2001, pp 168–170.&NA;Jaffe ES, Harris NL, Stein H, et alWorld Health Organization Classification of Tumours. Tumours of the Haematopoietic and Lymphoid Tissues.Lyon, FranceIARC Press2001168-1705. Zoldan MC, Inghirami G, Masuda Y, et al. Large cell variants of mantle cell lymphoma. Cytologic characteristics and p53 anomalies may predict poor outcome. Br J Haematol 1996;93:475–486.ZoldanMC]]InghiramiG]]MasudaY&etal;Large cell variants of mantle cell lymphoma. Cytologic characteristics and p53 anomalies may predict poor outcome.Br J Haematol199693475-4866. Banks PM, Chan J, Cleary ML, et al. Mantle cell lymphoma: a proposal for unification of morphology, immunologic, and molecular data. Am J Surg Pathol 1992;16:637–640.BanksPM]]ChanJ]]ClearyML&etal;Mantle cell lymphoma: a proposal for unification of morphology, immunologic, and molecular data.Am J Surg Pathol199216637-6407. Weisenburger DD, Kim H, Rappaport H. Mantle zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma. Cancer 1982;49:1429–1438.WeisenburgerDD]]KimH]]RappaportHMantle zone lymphoma: a follicular variant of intermediate lymphocytic lymphoma.Cancer1982491429-14388. Lennert K, Stein H, Kaiserling E. Cytological and functional criteria for the classification of malignant lymphomata. Br J Cancer 1975;31(suppl 2):29–43.LennertK]]SteinH]]KaiserlingECytological and functional criteria for the classification of malignant lymphomata.Br J Cancer19753129-439. Swerdlow S, Zukerberg L, Yang WI, et al. The morphologic spectrum of non-Hodgkin’s lymphomas with bcl1/cyclin D1 gene rearrangements. Am J Surg Pathol 1996;20:627–640.SwerdlowS]]ZukerbergL]]YangWI&etal;The morphologic spectrum of non-Hodgkin’s lymphomas with bcl1/cyclin D1 gene rearrangements.Am J Surg Pathol199620627-64010. Dunphy CH, Perkins SL. Large cell variants of CD5+, CD23- B-cell lymphoma/leukemia. Morphologic findings and bone marrow involvement. Arch Pathol Lab Med 2001;125:513–518.DunphyCH]]PerkinsSLLarge cell variants of CD5+, CD23- B-cell lymphoma/leukemia. Morphologic findings and bone marrow involvement.Arch Pathol Lab Med2001125513-51811. Ott MM, Ott G, Kuse R, et al. The anaplastic variant of centrocytic lymphoma is marked by frequent rearrangements of the bcl-1 gene and high proliferation indices. Histopathology 1994;24:329–334.OttMM]]OttG]]KuseR&etal;The anaplastic variant of centrocytic lymphoma is marked by frequent rearrangements of the bcl-1 gene and high proliferation indices.Histopathology199424329-33412. Dunphy CH, Dunphy FR. Prolymphocytic variant of mantle cell lymphoma: a previously undescribed form. J Surg Pathol 1998;3:47–50.DunphyCH]]DunphyFRProlymphocytic variant of mantle cell lymphoma: a previously undescribed form.J Surg Pathol1998347-5013. Viswanatha DS, Foucar K, Berry BR, et al. Blastic mantle cell leukemia: an unusual presentation of blastic mantle cell lymphoma. Mod Pathol 2000;13:825–833.ViswanathaDS]]FoucarK]]BerryBR&etal;Blastic mantle cell leukemia: an unusual presentation of blastic mantle cell lymphoma.Mod Pathol200013825-83314. Vasef MA, Medeiros LJ, Koo C, et al. Cyclin D1 immunohistochemical staining is useful in distinguishing mantle cell lymphoma from other low-grade B-cell neoplasms in bone marrow. Am J Clin Pathol 1997;108:302–307.VasefMA]]MedeirosLJ]]KooC&etal;Cyclin D1 immunohistochemical staining is useful in distinguishing mantle cell lymphoma from other low-grade B-cell neoplasms in bone marrow.Am J Clin Pathol1997108302-30715. Yang W, Zukerberg LR, Motokura T, et al. Cyclin D1 (bcl-1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia. Am J Pathol 1994;145:86–96.YangW]]ZukerbergLR]]MotokuraT&etal;Cyclin D1 (bcl-1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia.Am J Pathol199414586-9616. de Boer CJ, Schuuring E, Dreef E, et al. Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma. Blood 1995;86:2715–2723.de BoerCJ]]SchuuringE]]DreefE&etal;Cyclin D1 protein analysis in the diagnosis of mantle cell lymphoma.Blood1995862715-272317. Fu K, Weisenburger DD, Greiner TC, et al; Lymphoma/Leukemia Molecular Profiling Project. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood 2005;106:4315–4321.FuK]]WeisenburgerDD]]GreinerTC&etal;Lymphoma/Leukemia Molecular Profiling Project. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling.Blood20051064315-4321
