Case Report

Isoniazid‐lnduced Convulsions Part I—Clinical

Authors: JACK R. COYER MD, DAVID P. NICHOLSON MD

Abstract

ABSTRACTAcute isoniazid overdose and toxicity may be complicated by convulsions and death. Six patients are reported, one of whom ingested simultaneously 15 gm of isoniazid and 5 gm of pyridoxine hydrochloride (vitamin B6i); no convulsions resulted. In the light of this and other experience, suggestions are made for the use of pyridoxine in the treatment and prevention of acute isoniazid poisoning.

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References