Letter to the Editor

Malignant Fibrous Histiocytoma, Malignant Melanoma and Squamous Cell Carcinoma Arising from Different Areas in an Adult

Authors: Mevlut Kurt, MD, Sadettin Kilickap, MD, Sercan Aksoy, MD, Gulten Tekuzman, MD

Abstract

Malignant fibrous histiocytoma (MFH) is a well-defined and common malignant mesenchymal tumor of soft tissue occurring in late adult life.1 It usually involves the deep soft tissue and skeletal muscles of the proximal part of the extremities, especially the thigh.1 Skin cancers, such as basal cell carcinomas, squamous cell carcinomas (SCC) and melanomas represent the most frequent human malignancies. However, the presentation of all three types of cancer (MFH, SCC, and melanoma) in the same patient is very rare. This unique association was reported in a patient with burn scar.2 Herein, we report a case of MFH, SCC, and malignant melanoma arising in different areas over the course of fifteen years without a history of burn scar.

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References

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2.Alconchel MD, Olivares C, Alvarez R. Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars. Br J Dermatol 1997;137:793–798.
 
3.Nakanishi H, Tomita Y, Yoshikawa H, et al. Frequent p53 gene mutations in soft tissue sarcomas arising in bum scar. Jpn J Cancer Res 1999;90:276–279.
 
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5.Rhim KJ, Hong SI, Hong WS, et al. Aberrant expression of p53 gene product in malignant melanoma.J Korean Med Sci 1994;9:376–381.