Case Report
Metformin-Induced Vitamin B12 Deficiency Presenting as a Peripheral Neuropathy
Abstract
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References
1. Nathan DM, Buse JB, Davidson MB, et al. Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: update regarding thiazolidinediones: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2008;31:173–175.
2. Nathan DM, Buse JB, Davidson MB, et al; American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193–203.
3. Bailey CJ, Wilcock C, Scarpello JH. Metformin and the intestine. Diabetologia 2008;51:1552–1553.
4. Tomkin GH. Malabsorption of vitamin B12 in diabetic patients treated with phenformin: a comparison with metformin. Br Med J 1973;3:673–675.
5. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes. (UKPDS34) UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:854–865.
6. Ting RZ, Szeto CC, Chan MH, et al. Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med 2006;166:1975–1979.
7. Bell DS. Nondiabetic neuropathy in a patient with diabetes. Endocr Pract 1995;1:393–394.
8. Caspary WF, Zavada I, Reimold W, et al. Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides. Diabetologia 1977;13:187–193.
9. Schäfer G. Some new aspects on the interaction of hypoglycemia-producing biguanides with biological membranes. Biochem Pharmacol 1976;25:2014–2024.
10. Bauman WA, Shaw S, Jayatilleke E, et al. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000;23:1227–1231.
11. Deller DJ, Witts LJ. Changes in the blood after partial gastrectomy with special reference to vitamin B12. I. Serum vitamin B12, haemoglobin, serum iron, and bone marrow. Q J Med 1962;31:71–88.
