Case Report

Noncaseating Granulomatous Disease in Common Variable Immunodeficiency

Authors: NAVEEN KANATHUR, MD, RYLAND P. BYRD, JR., MD, CHERYL L. FIELDS, MD, THOMAS M. ROY, MD

Abstract

Patients with common variable immunodeficiency (CVID) are occasionally recognized to have a concurrent noncaseating granulomatous disease. The granulomatous disease (GD) associated with CVID shares many clinical properties typical of sarcoidosis. Some investigators speculate that the GD‐CVID is actually sarcoidosis that is expressed atypically because of the patient's immunodeficiency. Clinical differences, however, have led other investigators to speculate that the GD‐CVID is a distinct “sarcoid‐like” granulomatous process.

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