Original Article

OPEN ACCESS: Association Between System Factors and Acute Myocardial Infarction Mortality

Authors: Appathurai Balamurugan MD, DrPH, Martha Phillips PhD, MPH, James P. Selig PhD, Holly Felix PhD, MPA, Kevin Ryan JD, MA

Abstract

Objectives: We conducted a cross-sectional study to assess the association between healthcare system factors and death from acute myocardial infarction (AMI), in terms of access (distance to the hospital, mode of transportation), availability (emergency medical services, hospitals), and capability (emergency medical services’ 12-lead electrocardiogram capability, continuous percutaneous coronary intervention [PCI] and cardiothoracic surgical services), after accounting for individual and environmental factors.

Methods: Data on 14,663 deaths (in-hospital and out of hospital) and live hospital discharges as a result of AMI for 2012 and 2013 among Arkansas residents were obtained from the Arkansas Department of Health. A mixed-effects logistic regression model was used to account for nesting, in which an individual was nested within either a county or a hospital to evaluate the association of system factors with death from AMI.

Results: Deaths from AMI were significantly associated with two system factors: a 9.2% increase in the odds of deaths from AMI for every 10-mi increase in distance to the nearest hospital (odds ratio 1.092, 95% confidence interval 1.009–1.181) and a 64% increase in the odds of death from AMI among hospitals without continuous PCI capability (odds ratio 1.64, 95% confidence interval 1.15–2.34), after adjusting for individual and environmental factors.

Conclusions: A higher risk of AMI deaths was associated with healthcare system factors, especially distance to nearest hospital, and hospitals’ continuous PCI capability, even after adjusting for individual and environmental factors. A coordinated system of care approaches that mitigates gaps in these system factors may prevent death from AMI.

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References

1. State-specific mortality from sudden cardiac death-United States, 1999. MMWR Morb Mortal Wkly Rep 2002;51:123-126.
 
2. Boersma E, Primary Coronary Angioplasty vs. Thrombolysis Group. Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J 2006;27:779-788.
 
3. De Luca G, Suryapranata H, Ottervanger JP, et al. Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction: every minute of delay counts. Circulation 2004;109:1223-1225.
 
4. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 2003;361:13-20.
 
5. Rathore SS, Curtis JP, Chen J, et al. Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study. BMJ 2009;338:b1807.
 
6. Morland K, Diez Roux AV, Wing S. Supermarkets, other food stores, and obesity: the atherosclerosis risk in communities study. Am J Prev Med 2006;30:333-339.
 
7. Bell J, Mora G, Hagan E, et al. Access to healthy foods and why it matters: a review of the research. http://thefoodtrust.org/uploads/media_items/access-to-healthy-food.original.pdf. Published 2013. Accessed June 26, 2018.
 
8. Unger E, Diez-Roux AV, Lloyd-Jones DM, et al. Association of neighborhood characteristics with cardiovascular health in the multi-ethnic study of atherosclerosis. Circ Cardiovasc Qual Outcomes 2014;7:524-531.
 
9. Increasing physical activity. A report on recommendations of the Task Force on Community Preventive Services. MMWR Recomm Rep 2001;50(RR-18):1-14.
 
10. Diez-Roux AV, Nieto FJ, Caulfield L, et al. Neighbourhood differences in diet: the Atherosclerosis Risk in Communities (ARIC) Study. J Epidemiol Community Health 1999;53:55-63.
 
11. Diez-Roux AV, Nieto FJ, Muntaner C, et al. Neighborhood environments and coronary heart disease: a multilevel analysis. Am J Epidemiol 1997;146:48-63.
 
12. Buchmueller TC, Jacobson M, Wold C. How far to the hospital? The effect of hospital closures on access to care. J Health Econ 2006;25:740-761.
 
13. Avdic D. A matter of life and death? Hospital distance and quality of care. Evidence from emergency hospital closures and myocardial infarctions. https://cinch.uni-due.de/fileadmin/content/research/workingpaper/1501_CINCH-Series_avdic.pdf. Published 2014. Accessed June 26, 2018.
 
14. Canto JG, Zalenski RJ, Ornato JP, et al. Use of emergency medical services in acute myocardial infarction and subsequent quality of care: observations from the National Registry of Myocardial Infarction 2. Circulation 2002;106:3018-3023.
 
15. Luepker RV, Raczynski JM, Osganian S, et al. Effect of a community intervention on patient delay and emergency medical service use in acute coronary heart disease: the Rapid Early Action for Coronary Treatment (REACT) Trial. JAMA 2000;284:60-67.
 
16. Brown AL, Mann NC, Daya M, et al. Demographic, belief, and situational factors influencing the decision to utilize emergency medical services among chest pain patients. Rapid Early Action for Coronary Treatment (REACT) study. Circulation 2000;102:173-178.
 
17. US Census Bureau. American Community Survey. https://www.census.gov/programs-surveys/acs. Accessed October 12, 2015.
 
18. Anand SS, Islam S, Rosengren A, et al. Risk factors for myocardial infarction in women and men: insights from the INTERHEART study. Eur Heart J 2008;29:932-940.
 
19. Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004;364:937-952.
 
20. Balamurugan A, Delongchamp R, Im L, et al. Neighborhood and acute myocardial infarction mortality as related to the driving time to percutaneous coronary intervention-capable hospital. J Am Heart Assoc 2016;5:e002378.
 
21. Nallamothu BK, Bates ER, Wang Y, et al. Driving times and distances to hospitals with percutaneous coronary intervention in the United States: implications for prehospital triage of patients with ST-elevation myocardial infarction. Circulation 2006;113:1189-1195.
 
22. Graves BA. Access to cardiac interventional services in Alabama and Mississippi: a geographical information system analysis. Perspect Health Inf Manag 2010;7:1b.
 
23. Jollis JG, Granger CB, Henry TD, et al. Systems of care for ST-segment-elevation myocardial infarction: a report from the American Heart Association’ Mission: Lifeline. Circ Cardiovasc Qual Outcomes 2012;5:423-428.
 
24. Kansagra SM, Curtis LH, Schulman KA. Regionalization of percutaneous transluminal coronary angioplasty and implications for patient travel distance. JAMA 2004;292:1717-1723.
 
25. Concannon TW NJ, Kent DM, Griffith JL. Evidence of systematic duplication by new percutaneous coronary intervention programs. Circ Cardiovasc Qual Outcomes 2013;6:400-408.
 
26. Lieu TA, Gurley RJ, Lundstrom RJ, et al. Projected cost-effectiveness of primary angioplasty for acute myocardial infarction. J Am Coll Cardiol 1997;30:1741-1750.
 
27. Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. Mortality data. http://www.cdc.gov/nchs/deaths.htm. Accessed September 25, 2015.