Letter to the Editor

Operational Tolerance After Immunosuppressive Withdrawal in a Case with Renal Transplantation

Authors: Salih İnal, MD, Yasemin Erten, MD, Kürsad Öneç, MD, Fatma Ayerden Ebinç, MD, Turgay Arinsoy, MD

Abstract

To the Editor:


Renal transplantation is the first choice of replacement therapy in patients with end-stage renal disease. New immunosuppressive regimens have greatly reduced the risk of acute rejection and led to overall improvements in graft and patient survival. However, immunosuppressive drugs have numerous side effects and immunosuppression cannot prevent chronic rejection in most cases, which is the main cause of graft loss in renal transplantation.1

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References

1. Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003;349:2326–2333.
 
2. Roussey-Kesler G, Giral M, Moreau A, et al. Clinical operational tolerance after kidney transplantation. Am J Transplant 2006;6:736–746.
 
3. Berlanda M, Di Cocco P, Mazzotta C, et al. Clinical operational tolerance after kidney transplantation: a short literature review. Transplant Proc 2008;40:1847–1851.