Rapid Response

Optimal Definition of Chronic Kidney Disease as a Cardiovascular Risk State

Authors: Peter A. McCullough MD, MPH, FACC, FACP, FAHA, FCCP, Allan J. Collins MD, Joseph A. Vassalotti MD


This study and others suggest two simple and complementary measures should be done to identify chronic kidney disease (CKD). The random urinary albumin-creatinine ratio ≥30 mg/g and the estimated glomerular filtration rate <60 mL/min per 1.73 m2 identify CKD in predominantely younger and older age groups, respectively. In CKD, particularly in cases where both markers are positive, we can expect high rates of cardiovascular disease events.

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