Current Concepts

Oral Sulfonylureas for the Treatment of Type II Diabetes: An Update

Authors: WALTER A. SHANK JR. PharmD, ANTHONY D. MORRISON MD

Abstract

ABSTRACT: Oral hypoglycemic agents have been in clinical use since 1956 in the United States. Two new second-generation sulfonylureas, glipizide and glyburide, have been marketed recently. This article reviews the pharmacology of the oral sulfonylureas, compares the drugs from a safety and efficacy standpoint, and provides updated information regarding their use in the management of type II non-insulin-dependent diabetes mellitus.

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