Case Report

Paroxysmal Cold Hemoglobinuria Associated With Non-Hodgkin's Lymphoma

Authors: ALA I. SHARARA MD, RUSSELL E. HILLSLEY MD, TIM D. WAX MD, WENDELL F. ROSSE MD

Abstract

ABSTRACT: This report describes a patient with severe unexplained recurrent hemolytic anemia and congestive heart failure. Donath-Landsteiner antibodies, suggestive of paroxysmal cold hemoglobinuria (PCH), were detected. On postmortem examination, a diagnosis of non-Hodgkin's lymphoma, primarily involving the heart, was made. This previously undescribed association expands on the clinical and serologic spectrum of non-Hodgkin's lymphoma and PCH. Unexplained hemolytic anemia in the elderly should raise the suspicion of an underlying lymphoproliferative disorder.

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References