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SMJ // Article

Correspondence

Pineal Germinoma Followed by Hematogenous Metastases

Authors: Muhammad Wasif Saif, MD, Chris H. Takimoto, MD, PhD

Abstract

To the Editor:


Only 10 cases of extraneural hematogenous metastases of intracranial germinoma have been reported to date. We report one more case, that of a 23-year-old man with a pineal-body germinoma presenting as Parinaud syndrome. Hematogenous spread and vertebral column metastasis developed 7 months later.

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References

1. Haimovic IC, Sharer L, Hyman RA, Beresford HR. Metastasis of intracranial germinoma through a ventriculoperitoneal shunt. Cancer 1981; 48: 1033–1036.
 
2. Jennings MT, Gelman R, Hochberg F. Intracranial germ-cell tumors: Natural history and pathogenesis. J Neurosurg 1985; 63: 155–167.
 
3. Itoyama Y, Kochi M, Yamashiro S, et al. Combination chemotherapy with cisplatin and etoposide for hematogenous spinal metastasis of intracranial germinoma: Case report. Neurol Med Chir (Tokyo) 1993; 33: 28–31.
 
4. Pallini R, Bozzini V, Scerrati M, et al. Bone metastasis associated with shunt-related peritoneal deposits from a pineal germinoma: Case report and review of the literature. Acta Neurochir (Wien) 1991; 109: 78–83.
 
5. Balsitis M, Rothwell I, Pigott TJ. Systemic metastasis from primary intracranial germinoma: a case report and literature review. Br J Neurosurg 1989; 3: 717–723.
 
6. Gay JC, Janco RL, Lukens JN. Systemic metastases in primary intracranial germinoma: Case report and literature review. Cancer 1985; 55: 2688–2690.
 
7. Pena CE, Smith WI Jr. Metastasizing cerebral germinoma. Ann Neurol 1984; 16: 94–95(letter).
 
8. Galassi E, Tognetti F, Frank F, Gaist G. Extraneural metastases from primary pineal tumors: Review of the literature. Surg Neurol 1984; 21: 497–504.
 
9. Motomochi M, Makita Y, Nabeshima S, et al. A case of intracranial germinoma with multiple remote metastases [in Japanese]. No Shinkei Geka 1980; 8: 563–570.
 
10. Rubery ED, Wheeler TK. Metastases outside the central nervous system from a presumed pineal germinoma: Case report. J Neurosurg 1980; 53: 562–565.
 
11. Borden SIV, Weber AL, Toch R, Wang CC. Pineal germinoma: Long-term survival despite hematogenous metastases. Am J Dis Child 1973; 126: 214–216.
 
12. Tompkins VN, Haymarker W. Metastatic pineal tumors: A clinicopathologic report of two cases. J Neurosurg 1950; 7: 159–169.
 
13. Allen JC, Kim JH, Packer RJ. Neoadjuvant chemotherapy for newly diagnosed germ-cell tumors of the central nervous system. J Neurosurg 1987; 67: 65–70.
 
14. Asai A, Matsutani M, Kohno T, et al. Subacute brain atrophy after radiation therapy for malignant brain tumor. Cancer 1989; 63: 1962–1974.
 
15. Packer RJ, Sutton LN, Atkins TE, et al. A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J Neurosurg 1989; 70: 707–713.
 
16. Watterson J, Priest JR. Control of extraneural metastasis of a primary intracranial nongerminomatous germ-cell tumor: Case report. J Neurosurg 1989; 71: 601–604.