Abstract

AbstractBackground.We retrospectively compared the decline of cardiac troponin I after acute myocardial infarction (AMI) in patients with normal renal function and those with end-stage renal disease (ESRD) who were receiving hemodialysis. Methods.We reviewed 257 cases with a discharge diagnosis of AMI or AMI plus ESRD; 222 were excluded due to inadequate data or evidence of ongoing myocardial necrosis. Decline of cardiac troponin I values was followed over a mean (± SD) of 2.75 ± 1.2 days in patients with normal renal function and 2.7 ± 2.0 days in ESRD patients. Average apparent half-life and apparent elimination rate constant of troponin I were compared between groups. Results.Of 35 patients with AMI, 16 had ESRD and were receiving hemodialysis, and 19 had normal renal function. Mean (± SD) apparent half-lives of troponin I in the ESRD group and the group with normal renal function were 1.48 ± 0.77 days and 1.08 ± 0.63 days, respectively. The mean apparent elimination rate constants of cardiac troponin I were 0.64 ± 0.33 days–1 in the ESRD group and 0.91 ± 0.55 days–1 in the group with normal renal function. Conclusion.The difference in apparent half-life and apparent elimination rate constant of cardiac troponin I between patients with normal renal function and those with ESRD is not statistically significant.