Primary Article

Prevalence of Drug-Induced Immunologic Changes in Hypertensive Jamaicans

Authors: GERALD A.C. GRELL MB, MRCP, WENDELL A. WILSON MD, OWEN JAMES MB

Abstract

Of 137 hypertensive black Jamaicans who took methyldopa for a mean period of 36 months, a positive ANA was found in 1.5% and a positive direct Coombs test in 0.7%. In 36 patients in whom hydralazine was included in the therapeutic regimen, a positive ANA was seen in only 6%. These results suggest that in black populations, immunologic abnormalities induced by antihypertensive drugs are less common than has been reported in white patients.

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References