Case Report

Profound Transient Thrombocytopenia Associated with 90Yttrium Microsphere Therapy for Inoperable Hepatoma

Authors: Chia-Wei Yang, MD, Hsu-Heng Yen, MD, Wei-Wen Su, MD, Yang-Yuan Chen, MD, Maw-Soan Soon, MD

Abstract

The use of 90Yttrium microspheres to treat unresectable hepatoma is increasing worldwide. Therapeutically, 90Yttrium microspheres show promising increases in survival and tumor response, as well as acceptable toxicities. Here, we report on a 67-year-old man with hepatitis C-related advanced-stage hepatoma. This patient received selective internal radiation therapy (SIRT) using 90Yttrium microspheres (SIR-Spheres®). The patient displayed bone marrow suppression that resulted in a transient yet profound thrombocytopenia. To our knowledge, this is the first case of a hematologic complication as a consequence of the use of commercially available 90Yttrium microsphere devices.

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