Primary Article

Radiation Therapy for Renal Transplant Rejection Reactions

Authors: WILLIAM J. PEEPLES MD, DUANE G. WOMBOLT MD, ANAS M. EL-MAHDI MD, ScD, CORNELIUS I. C. TURALBA MD

Abstract

ABSTRACTForty-four renal transplant patients were given radiation therapy for severe rejection phenomena. The 29 patients who had only one course of irradiation had a 52.3% successful function rate. Fifteen patients received from two to four courses of irradiation with an ultimate 60% rate of sustained function. Fifty patients who received only steroid and other medical management but no irradiation had a 60% rate of successful renal function. In the irradiation group, no patient whose creatinine level did not respond to radiation therapy maintained a functioning kidney. The data indicate that the overall successful function rate is maintained by radiation therapy in patients who show severe allograft rejection phenomena.

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References